Set against the vibrant backdrop of one of the world's hottest cities - Miami - private pathologist Dr. Beaumont Rosewood, Jr. must crack a case that hits close to home. As he begins his investigation, Detective Annalise Villa gives him a run for his money as they cross paths and are forced to work together to help the Miami PD solve the case.
When an unexpected piece of evidence surfaces in the 305, Rosewood and Villa attempt to solve a serious crime involving a very well-off Miami man. Meanwhile, Rosewood struggles to balance a new romantic interest with the demands of his mother, and Villa runs into trouble on the job.
A series of mysterious deaths pulls Rosewood off the glamorous promenades of South Beach when a troubled young genius stands accused of murder, and the only one who believes in his innocence is Rosewood. He must contend with a colorful new adversary, escalating health problems and a burgeoning romantic relationship, while Villa's inability to connect with people hampers her own ability to investigate the case.
Rosewood and Villa must prove a brilliant doctor murdered two patients, despite a limited amount of evidence; Rosewood receives a letter containing potentially life-altering news.
Rosewood and Villa seek justice for a murdered ex-con who had ties to a Little Haiti gang; Villa struggles with her recent dreams; Rosewood faces an unexpected turn in his relationship with Kat.
Hornstock is a murder suspect when his third ex-wife is killed, so he turns to Rosewood and Villa to help him clear his name.
Rosewood testifies for the prosecution during a murder trial, going up against his father, the expert witness for the defense; a surprising announcement has unexpected consequences.
A bounty hunter who happens to be Hornstock's former partner helps Rosewood and Villa track a murderer; Pippy receives an opportunity that could launch her music career; Villa attempts to reconnect with her mother.
Amidst the glitz and glamour of Miami Fashion Week, there's a plot to kill one of the city's hottest new designers, who turns to Rosewood for help. As the case takes Rosewood and Villa from the catwalk to the perp walk, Rosewood learns of his shared past with the victim. When he enlists the aid of his best friend, Dr. Mike Boyce, Rosewood unintentionally gives Villa the jolt she needs to get back into the dating pool. Potential love also is in the air for Donna, who tries her hand at online dating. Meanwhile, Pippy and TMI find their romance on the skids when Pippy discovers TMI has kept an important secret from her.
Rosewood and Villa join forces to locate a maniacal serial killer. The craftiness of the killer makes it extremely difficult for the partners.
Picking up where the series left off after the fall finale, the search for the serial killer takes a very personal turn, as Rosewood and Villa must follow a trail of clues left for Rosie, before another victim falls prey. As things heat up between Villa and Mike, Villa escapes by throwing herself deeper into the case, which inevitably pushes her closer to Rosewood. Meanwhile, Donna intervenes when Pippy decides to give TMI's absentee mother a piece of her mind. Plus, the Chief position is Hornstock's, if he is willing to pay a stiff price.
Hornstock forces Villa to pick a new partner, and she immediately clashes with the one assigned to her. After learning she cost Hornstock the job as Chief, Villa tries to make herself less of a liability, which reveals a surprising pattern in her life. Meanwhile, the death of a victim forces Pippy to offer her assistance in the investigation and to revisit her past. The case stirs up old wounds for the entire Rosewood family and creates new ones for her and TMI. Meanwhile, Rosewood’s slight health scare leads him in search of a new cardiologist.
Rosewood’s partnership with Villa faces an uncertain future when she’s paired with a recent transfer to the East Miami PD, with whom she shares a past. As Villa and her new partner investigate the death of a suburban dentist who ran a yuppie drug ring, Rosewood can’t shake the feeling that his “replacement” knows more about the victim’s narcotics business than he’s letting on. Meanwhile, a new medical examiner, Dr. Anita Eubanks, is brought in to help with the investigation and Hornstock’s insecurities hinder his ability to handle the public relations side of the case, forcing him to turn to an unlikely source for help
Rosie insists on celebrating his and Villa's nine-and-a-half month anniversary as partners, which lands them in the middle of a case involving none other than Julius "Joo-Joo" Beeman, their confidential informant. But, this time, Joo-Joo is the prime suspect. As Rosie and Villa work to uncover the truth, even if it means putting Joo-Joo away for life, they discover a whole new side of him they never saw coming. Meanwhile, Villa's choice for her new home has Rosie worried about the new path she's on, Pippy and TMI struggle to balance old friends and family, and Hornstock has trouble reading signals from the new, badass, female chief of police.
While at an out-of-town forensic pathology convention, Rosewood unintentionally reveals the blueprint to commit the perfect murder during a speech to the convention attendees. Tormented, and armed only with a hunch, Rosewood enlists Villa to help solve the crime, and while investigating undercover, sparks fly unexpectedly between them. Hornstock and Floyd Butters are called upon for extra help. Meanwhile, Pippy and TMI have locked themselves in the lab overnight to help with the investigation and TMI receives an unexpected visit from her estranged father.
Rosewood investigates the suspicious death of a man with medical issues similar to his own, which forces him to slightly adjust the tint on his Rosie-colored lenses and confront his own mortality. Also adding to his stress, he finds himself trapped between Donna and his girlfriend/cardiologist, Dr. Erica Kincaid, and their dueling opinions over what’s best for Rosewood – medically and personally. Meanwhile, Hornstock enlists the help of Villa as he attempts to reconnect with one of the witnesses linked to the case...his estranged teenage daughter, Sophie
Rosewood and Villa investigate the murder of a telenovela star, holding a mirror up to their own relationship as they explore a world of off-screen soap and intrigue. Meanwhile, Erica strong-arms her way into Rosewood's life, much to Donna's chagrin. Then, Rosewood's precious GTO is stolen, and Villa reconnects with her mother, Daisie.
When two bodies and lot of cash wash up on the shore of Miami Beach, Rosewood and Villa are forced to work with a rival private pathologist who threatens Rosewood’s contract with the East Miami Police Department. Meanwhile, Daisie moves in with Villa and oversteps her boundaries, while TMI tries to keep up with Pippy and Cassie.
Despite each being at the top of their fields, Villa and Rosewood are stumped when a local musician and king of catchy jingles suddenly keels over in his studio with no discernable cause of death. Meanwhile, Donna enlists Mitchie to investigate Erica’s “missing year”.
When a patient of Erica Kincaid's dies on the table, Rosewood steps in to help solve what turns out to be the murder of an undercover ATF agent. But when Villa connects with a cold case detective, it turns out this case has more angles than they ever imagined.
An old flame of Rosewood's shakes up Rosewood's life when she returns to enlist his help in finding a wealthy patient of hers who's disappeared. But when the man's body surfaces, triggering a murder investigation, things are not what they appear to be. As the bizarre turns of this case come to a head, so does Rosewood's personal life as he is pushed to make decisions regarding all the women in his world.
Rosie and Villa find themselves caught in the middle of an explosive investigation that makes them question whether justice really is blind. Meanwhile, as the decks are cleared for Rosie and Villa to finally act on their feelings, Rosie stumbles on some information that forces him to embark on his own private investigation behind Villa’s back. What he finds could change their relationship forever. Also, Pippy and TMI are moving closer to their wedding day, Donna’s behavior leads Rosewood and Pippy to suspect she has a new man in her life and an error from Hornstock’s past comes back to haunt him.
A new captain shakes things up at the East Miami Police Department, and Miami's young, hot-shot mayor gets personally involved when his promising young mentee is mysteriously murdered.
When Rosie and Villa discover that their murder victim has a death certificate from three years ago, they’re charged with uncovering the truth around his identity. As they struggle to solve the mystery around his death, as well as around Eddie’s, TMI tries to reconnect with Pippy and Donna finds it hard to keep a secret from her family.
Rosewood and Villa travel to New York to investigate Eddie's death, while Slade and Hornstock team up to take down a Miami prostitution ring.
When a boatload of Miami’s hottest young partygoers discover a body during a booze cruise, Rosie and Villa must dive into the world of deep sea treasure hunting in order to solve the case.
When a man stumbles into Magic City Lab requesting to pay in advance for his own autopsy, the team is confused and skeptical - until that same man turns up dead the very next day.
Rosewood and Villa enlist the help of Miami's brightest pathology students to investigate a cold case double murder, and their findings lead to a revelation that affects the entire Rosewood family.
When Miami's most glamorous model dies the night after a beachfront photo shoot, Rosie and Villa are plunged into the glitzy and cutthroat world of one of the city's favorite pastimes - plastic surgery.
The team thinks they have an open-and-shut case on their hands when a food truck vendor with a checkered past is discovered dead, but the case becomes more complicated when the victim is revealed to have had strong ties to Slade's past.
Rosewood and Villa's tireless investigation of Gerald's case leads them to Cuba, where they must solve two new mysteries: what really happened to Amelia's body, and what's the truth about Gerald's daughter, Michelle? Meanwhile TMI brings in her old roommate, Dr. Daisy Wick to help the team decipher the evidence.
A hostage situation erupts at the East Miami Police Department, and Rosewood, Villa and Slade are trapped on the inside. Rosewood forms a strong bond with their captor and must solve his biggest medical mystery to date in order to keep his team alive.
The team is thrown for a loop when the mummified body of a notorious music producer is found on a yacht. Meanwhile, Rosewood is forced to deal with a shocking revelation about Tawnya.
When an escape artist is found dead in a wooden trunk, Rosewood and Villa must unravel a case packed with illusions and deception. Meanwhile, Hornstock's days with the East Miami PD may be numbered and Rosewood gets to know Adrian to make sure he is the right guy for Villa.
When a victim, presumed dead, wakes up on Rosie's autopsy table, the team is thrown into a world in which people go to great lengths to keep their secrets hidden. Both Rosie and Villa are forced to re-examine the meaning of family, and Rosie's search for a Magic City Lab investor leads him to a surprising candidate.
A mysterious death in an empty high-rise pulls Rosie and Villa into the inner circle of a former child star who may be planning a comeback. Meanwhile, Rosie is feeling the effects of Donna's involvement at Magic City Lab, and shocking revelations from Hornstock and Rosie elevate their relationship to a new level.
A criminal lures Rosewood to the murder scene of a former tech millionaire and, in doing so, forces Rosie to re-examine a case from his past.
The hunt for a counterfeit currency kingpin allows the team to get a glimpse into Villa's past. Meanwhile, Rosie receives surprising news about his recent health issue.
When a female astronaut is found dead, Rosie and Villa launch into an investigation of America's space program. Rosie navigates new dynamics regarding his latest health issue, and Villa's long-lost brother returns to Miami.
Rosewood and Villa are tasked with solving the murder of a woman whose body was found frozen solid. Outside the precinct, Villa's brother meets the important people in her life, but isn't yet ready to have a reunion with his mother.
Rosewood and Villa head back to Villa's roots in Little Havana to investigate a vigilante who may be guilty of murder. Villa learns that her brother, Marcos, has a surprising connection to the case, and Rosie receives news of a complication regarding his kidney transplant.
Rosie, Villa and TMI head to a small town to investigate the murder of its former mayor. Rosie struggles with feelings of guilt, as Slade faces complications following his kidney donation.
Rosewood and Villa are pulled into the world of human trafficking to investigate the death of a school teacher, and a surprising insight into Slade's past draws Rosie and Villa closer than ever before.
Season Finale. Rosewood, Villa, Slade and Hornstock work to take down a highly skilled group of criminals suspected of a jewelry store heist, and Rosie decides that someone from the inner circle should run a new Magic City Lab on the west coast.
