Crossing more than 10 years in their career, they start to face that era where they reach various roads to walk on, their work, and their private lives. Aizawa Kousaku left the lifesaving center of Shoyo University Hokubu Hospital, devoting himself as a brain surgeon aiming high to perform operations every day. Shiraishi Megumi, due to the insufficient aide in the Shohoku lifesaving center now is struggling as the leader of the flight doctor staff. Once with them in aiming to be a flight doctor, Hiyama Mihoko left Shohoku Hospital and is now an obstetrician and gynecologist in a perinatal care center. Saejima Haruka even now continues to be an ace flight nurse. And Fujikawa Kazuo, together with Shiraishi supports Shohoku lifesaving, has become a lifesaving doctor with specialization on orthopedic surgery.
「ドクターヘリ」に乗るフライトドクターを目指す若者たちの奮闘を描いたドラマの新シリーズ。藍沢（山下智久）、白石（新垣結衣）らは、10年以上のキャリアを経て、おのおの人生と向き合っていた。そんな折、翔北救命救急センターに、フライトドクターを目指すフェロー・名取（有岡大貴）、灰谷（成田凌）らがやって来る。
藍澤（山下智久飾）離開急救中心，以腦外科醫師身分努力專研醫術。白石（新垣結衣飾）則是成為翔北急救中心的組長，為了人手不足而煩惱。緋山（戶田惠梨香飾）也離開急救中心，努力專攻婦產科。藤川（淺利陽介飾）則是和白石在翔北急救中心繼續奮鬥。4人過去的指導醫師橘啟輔（椎名桔平飾）依然守護著他們，不過面對急救中心嚴重人手不足，很希望藍澤與緋山能回來幫忙...
