Sergeant Abraham Neumann and Detective Vera Cortez, operatives from Planetside Security (P-SEC), are investigating a local disturbance at Apartment 23 Row D4 B Block, inhabited by a surveyor named Lisa and her husband Tom who works at the morgue.
Chapter One begins with a very bloody Sergeant Abraham Neumann from P-SEC making a security log, with blood on the walls all around him. He says that if a planetside survivor finds the security log, they are doomed, and should not bother to escape. He warns that if anyone finds the log, they are to order the colony be nuked, so "humanity doesn't suffer the same fate."
Dr. Tom Sciarello is at a press conference at Union Square mourning the death of Katie, his nurse and assistant of five years. He mentions that her call to P-SEC saved his life and that he would willingly trade it back for hers. As he says this, Katie appears as an apparition and tells Tom that he has more important things to do, that he's "gotta stop them." In shock, Tom breaks down and is escorted off the podium.
Sergeant Abraham Neumann comments to Dr. Tom Sciarello how "half the colony is walking around like it's the end of the world". Sciarello recalls his vision of Katie's ghost: he claims that despite being a life long atheist and skeptic and convinced the vision was an hallucination, if he were a spiritual man, he'd be praying right now. Neumann is befuddled how a group of blue-collar miners can get "so worked up over a rock", but Sciarello points out it's the same thing as doing so about a chalice or a scroll. He adds Hanford Carthusia finally allowed him access to Natasha Deshinov and plans to question her.
Issue Four starts with Neumann and Dr. Sciarello walking along a hallway, discussing how things are after the marker has been taken up to the ship. While Neumann states that crimes have gone down, Sciarello replies that "Almost 20% percent of the staff have psych problems". When they reach their destination Neumann wonders "If she's not cured why did [Sciarello] take her out of the secure chambers?". Sciarello replies that "She's not dangerous anymore, but far from cured". We quickly discover that Natalia Deshinov is inside the room.
Neumann is still confused about the situation with the Marker and what it does. "All right, fine, so it mutates dead bodies, but what killed them in the first place? This... stuff?" Marla replies that she's not sure. She attempts to call the Ishimura but with no luck as the comm is still down.
The final comic begins with the colonist who was investigating an infected body getting impaled by the now-infected person, who has transformed into a necromorph. Marla and Neumann begin to lead the group away through the Necromorphs, but many of the colonists are slaughtered in the escape.
