Pranksters Jeremiah and Big Ox set up their overly flirtatious friend Cody by giving him a massage with a bikini model, but he'll learn to keep his hands to himself when he discovers just who the model is. When their city slicker buddy Jay makes fun of their redneck ways, Jeremiah and Ox bring him on the worst hunting trip ever. They send him sailing aboard a porta potty in a gator-filled swamp. Casey asks Jeremiah to babysit their son, but when she gets home, there's a gigantic surprise waiting for her in the crib.
The guys recruit a professional stunt driver and put him behind the wheel of a taxi to take their ride-mooching friend Jared on the scariest trip of his life. Jeremiah hosts a fake TV show about relationships and introduces an insanely jealous girlfriend to a make-believe mistress. After one too many daytime naps, the guys give Drew a good ole fashion bayou rude awakening.
When Jeremiah and Big Ox find out that Drew's girlfriend keeps bugging him for a new convertible, the guys make her wish come true ... by sawing the top off her car. Then, the guys get back at a messy roommate by turning his pigsty into a zoo, literally. Back at home, Casey demands that Jeremiah do more housework, so he gets busy booby trapping their whole house.
Jeremiah and Ox help a son prank his cocky dad by hijacking his model plane and setting it on course for destruction. When a friend wants his wife to face her fear of water, she's in for a real croc-shock when the guys take her on a cruise in gator-filled lake in a sinking ship. And, Drew literally becomes the butt of Ox's joke, when he attempts an "atomic sit-up."
The guys prank a golf fanatic's wife by throwing a golf tournament in her backyard -- redneck style. And they take fine dining to new lows in an attempt to get a husband to appreciate his wife's home cooking. Then, Jeremiah connects himself to a labor pains simulator to prove to Casey that men can handle more pain than women.