What is life in prison really like for the fastest growing segment of incarcerated Americans? Chris Cuomo is granted unprecedented access to New York State’s only maximum security prison for women, witnessing some of the most important moments of some of the inmates’ lives. From the first day of a young woman who put her love of drugs over her two young children, to a dominatrix who killed two of her customers and is now allowed conjugal visits with a husband she met on a prison dating website. Cuomo talks to the warden about the problems of drugs in prison, and whether rehabilitation is possible: spending time with a woman who has spent 26 years in prison for murdering her own grandmother as she waits to find out whether her fifth parole hearing will finally set her free.