Luciano takes over Vito Genovese's heroin ring in Italy, then rejoins Meyer Lansky at a mob summit in Cuba. Genovese and Carlo Gambino plot against the mob leadership, and Bugsy Siegel's dream of Las Vegas turns deadly.
In the second season opener, Johnny Torrio mentors Capone in Brooklyn, and then the two reunite in Chicago, where their bootlegging enrages local Irish gangsters.
A betrayal destroys peace in Chicago and Torrio and Capone seek revenge against the Irish gangs. Meanwhile, the Beer Wars make Capone Chicago's top gangster.
Capone uses the St. Valentine's Day Massacre to assert his power over his enemies. Meanwhile, President Hoover takes notice; and dispatches Elliot Ness to take on Capone.
With Capone in jail, Frank Nitti, Paul Ricca and Joe Accardo take over. Meanwhile, a Hollywood scandal presents Sam Giancana with a chance to prove himself.
In the second-season finale, Joe Accardo and Sam Giancana have a falling out and the fate of the Outfit rests on the outcome. Meanwhile, Joe Accardo cleans up loose ends before retiring.