Two underachieving Cannabis smoking, Silas (Method Man) and Jamal (Redman (rapper)) are visited by the ghost of Silas's recent deceased friend Ivory (Chuck Deezy (screenwriter)). Ivory was cremated and Silas used his ashes as fertilizer for a new batch of Cannabis (drug). While both are sitting in the parking lot before taking their "THC" (Testing for Higher Credentials, a parody of the SAT in allusion to Tetrahydrocannabinol) exams for college, neither is able to smoke his individual marijuana stash without the help of the other.
When a pair of friends uncover a weed Bible, their magical stash gets stolen, sending them on a pot-fueled quest through Atlanta to find it.