Calvin Cambridge and his two best friends, Murph and Reg Stevens, live in an orphanage. Murph is the youngest of the trio, and has a very close bond with Calvin. At night they all have to sell chocolate for the awkward orphanage director, Stan Bittleman, after each home game of the (fictional) NBA team, the Los Angeles Knights.
Jerome and his friends are very adept at streetball, but are no match for the older boys in their neighborhood. When the friends realize a streetball team called Game On is coming to town to look for talent, they practice hard and work to win.