Two years following their success in the 21 Jump Street program, Schmidt (Jonah Hill) and Jenko (Channing Tatum) are back on the streets chasing narcotics. However, after failing in the pursuit of a group of drug dealers led by Ghost (Peter Stormare), Deputy Chief Hardy (Nick Offerman) puts the duo back on the program to work for Captain Dickson (Ice Cube) – now located across the street at 22 Jump Street. Their assignment is to go undercover as college students and locate the supplier of a drug known as "WHY-PHY" (Work Hard? Yes, Play Hard? Yes) that killed a student photographed buying it on campus from a dealer.