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Dishonorably discharged special forces operative Wade Wilson meets and falls in love with a prostitute. A year later, she accepts his marriage proposal, but shortly afterwards Wade is diagnosed with terminal cancer. He leaves Vanessa without warning so that she will not have to watch him die and enters into a rogue experiment that saves his life, leaves him with accelerated healing powers, but terrible scars. Wade adopts the alter ego Deadpool and armed with his new abilities, he hunts down the man who nearly destroyed his life.

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