The film is a series of vignettes with Matthew Lillard's sex advice is intercut within every couple segments. Mike (Ryan Pinkston) tries to impress his crush, Stacy (Cherilyn Wilson). Fred (Michael Cera) meets a girl (Joanna Garcia) online and they arrange for "menacing action", only for Fred to break into the wrong apartment. The promiscuous Betty (Ashley Schneider) going to the "next level" (kinkier and more outrageous sexual adventures) with Chuck (Frankie Muniz), and later Fred. Justin (Andy Milonakis) buys a vibrating vagina and falls in love with it, all the time while crushing on another girl; the vibrating vagina has a personality of its own and commits "suicide" when Justin rejects it.