In Buffalo, New York, a man named Carl picks up a woman he thinks is a prostitute and takes her to his home. When he spots that she is transsexual, he angrily murders her, cuts up the body, and places the pieces in a freezer. Meanwhile, Mike Fletcher, a detective, becomes obsessed with the case, which is under threat of being shut down due to its inactivity. A troubled Thanksgiving holiday dinner reveals that he has been ignoring his family, including his rebellious daughter, Abby. Following an argument with her mother, Abby sneaks out of the house to be with her boyfriend Tad. At the diner where he works, Tad breaks up with her, and Abby runs outside. Tad sees her talk to a person in a car; when he next looks, she has disappeared. Carl kidnaps Abby and chains her up in his basement, where he keeps two other young women prisoner, Brittany and Lauren, who suffer from Stockholm Syndrome.
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