The film follows the life of Jennifer Hills, continuing her story from ''I Spit on Your Grave (2010 film)''. After Jennifer survived her assault and exacted revenge on the men who raped her, she avoided conviction for her killing spree and settled in Los Angeles. She is no longer an aspiring writer and now devotes herself between working as an assault hotline operator and going to group counseling under the assumed name Angela Jitrenka. She is also periodically shown attending personal therapy for her ordeal. Jennifer's scarring experience has left her highly distrustful and defensive towards most men, including her colleague Matthew, who has a seemingly genuine interest in her.