In California, an alcoholic named Julia (Tilda Swinton) is out of control, partying every night, and waking up in unknown homes with no memory of the previous night. Her reckless behavior costs her her job and she begins to go broke. She soon meets a mother, Elena (Kate del Castillo), at an Alcoholics Anonymous meeting. Elena takes Julia into her apartment after finding her passed out on the pavement one night. The following morning Elena explains that she wants to kidnap her son Tom (Aidan Gould) from his wealthy grandfather and asks Julia to participate for $50,000. Julia declines, but after some time changes her mind. She visits an old friend to ask for his cooperation, but her offer is refused. She rides to the Mexican border, kidnaps the little boy and blackmails Elena's father-in-law for $2 million. The police discover her whereabouts and she flees, accidentally crashing her car through the wall dividing the United States and Mexico. There, the boy is kidnapped in turn by Mexican kidnappers. Her friend Mitch (Saul Rubinek) arrives in Mexico and gives Julia the ransom money. During the exchange, the Mexican kidnappers escape with the money, leaving the boy safely with Julia.
Julia, séductrice et grande gueule a de plus en plus de mal à cacher son alcoolisme et finit par perdre pied. Une rencontre l'entraîne dans un engrenage infernal qui l'amène à kidnapper Tom, un enfant de huit ans. Commence alors une fuite sans issue à travers le sud des Etats-Unis et qui les conduira jusqu'au Mexique.
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