The film opens with a news montage explaining that it is set in a Dystopian near-future in which George W. Bush has been elected to a fourth term. The United States Congress has been disbanded; public nudity is banned; the United States is embroiled in wars with France, Iraq, Afghanistan, Iran, Pakistan, Syria, Venezuela, Canada, and Alaska. Due to there not being enough soldiers to fight in all the wars, a secret laboratory run by Dr. Chushfeld in fictional Sartre, Nebraska, has developed a virus to re-animate dead Marines and send them back into battle. However, this virus has broken containment and infected test subjects and scientists, and they are at risk of escaping from the lab. A team of Marines code-named the "Z" Squad is sent in to destroy the zombies. One of the Marines named Byrdflough (Zak Kilberg) is bitten but escapes. He ends up in an alley outside an underground strip club named "Rhino". The Marine dies and awakens as a zombie who goes into the strip club.