| Name | Type | Role | |
|---|---|---|---|
| Lee Ah-in | Musical Guest | Momoland - Ahin | |
| SUGA | Musical Guest | BTS - Suga | |
| Park Jin-young | Musical Guest | Got7 - Jinyoung | |
| Kwon Soon-young | Musical Guest | Seventeen - Hoshi | |
| Kim Ji-yeon | Musical Guest | WJSN - Bona | |
| Choi Hyo-jung | Musical Guest | Oh My Girl - Hyojung | |
| Choi Ye-na | Musical Guest | Iz*One - Yena | |
| Kang Daniel | Musical Guest | Wanna One - Daniel | |
| Kim Jong-kook | Musical Guest | Kim Jong-Kook | |
| Park Ji-hoon | Musical Guest | Wanna One - Jihoon | |
| Kim Chan-mi | Musical Guest | Chungha | |
| Wen Junhui | Musical Guest | Seventeen - Jun | |
| Lee Byung-yoon | Musical Guest | BewhY | |
| Jung Kook | Musical Guest | BTS - Jungkook | |
| Lee Jin-suk | Musical Guest | WJSN - Yeoreum | |
| Honda Hitomi | Musical Guest | Iz*One - Hitomi | |
| Xu Minghao | Musical Guest | Seventeen - The8 | |
| Yoon Ji-sung | Musical Guest | Wanna One - Jisung | |
| Bae Yu-bin | Musical Guest | Oh My Girl - Yubin | |
| Moon Ji-hoon | Musical Guest | Swings | |
| Nancy Jewel Mcdonie | Musical Guest | Momoland - Nancy | |
| Jin | Musical Guest | BTS - Jin | |
| Kim Yu-gyeom | Musical Guest | Got7 - Yugyeom | |
| Joshua Hong | Musical Guest | Seventeen - Joshua | |
| Chu So-jung | Musical Guest | WJSN - Exy | |
| Sunmi | Musical Guest | Sunmi | |
| Lee Chae-yeon | Musical Guest | Iz*One - Chaeyeon | |
| SEVENTEEN | Musical Guest | "Oh My!", "Flower", "Bring It", "Getting Closer" | |
| JJ Lin | Musical Guest | JJ Lin | |
| Park Woo-jin | Musical Guest | Wanna One - Woojin | |
| Roy Kim | Musical Guest | Roy Kim | |
| GOT7 | Musical Guest | "Lullaby (Ballad Ver.)" | |
| Jo Dong-rim | Musical Guest | Mommy Son | |
| V | Musical Guest | BTS - V | |
| Kim Hyun-jung | Musical Guest | WJSN - Seola | |
| Jo Yu-ri | Musical Guest | Iz*One - Yuri | |
| Kim Min-gyu | Musical Guest | Seventeen - Mingyu | |
| Kwon Eun-bi | Musical Guest | Iz*One - Eunbi | |
| Bae Jin-young | Musical Guest | Wanna One - Jinyoung | |
| Hyun Seung-hee | Musical Guest | Oh My Girl - Seunghee | |
| Mark Tuan | Musical Guest | Got7 - Mark | |
| Kim Na-yun | Musical Guest | Momoland - Nayun | |
| RM | Musical Guest | BTS - RM | |
| Park Soo-bin | Musical Guest | WJSN - Soobin | |
| Yoon Jeong-han | Musical Guest | Seventeen - Jeonghan | |
| Hansol Vernon Chwe | Musical Guest | Seventeen - Vernon | |
| Jang Da-hye | Musical Guest | Heize | |
| Kim Chaewon | Musical Guest | Iz*One - Chaewon | |
| Park Jun-young | Musical Guest | Bizzy | |
| Lee Dae-hwi | Musical Guest | Wanna One - Daehwi | |
| Jeon Sang Hyun | Musical Guest | Paloalto | |
| Jimin | Musical Guest | BTS - Jimin | |
| BamBam | Musical Guest | Got7 - BamBam | |
| Momoland | Musical Guest | "BAAM", "Bboom Bboom" | |
| Son Ju-yeon | Musical Guest | WJSN - Eun Seo | |
| An Yu-jin | Musical Guest | Iz*One - Yujin | |
| Lee Ji-hoon | Musical Guest | Seventeen - Woozi | |
| Miyawaki Sakura | Musical Guest | Iz*One - Sakura | |
| Lai Guanlin | Musical Guest | Wanna One - Guanlin | |
| Choi Ye-won | Musical Guest | Oh My Girl - Arin | |
| Lim Jae-beom | Musical Guest | Got7 - JAY B | |
| Lee Joo-won | Musical Guest | Momoland - JooE | |
| Wanna One | Musical Guest | "Beautiful (MAMA Ver.)", "Spring Breeze", "Energetic" | |
| Lee Lu-da | Musical Guest | WJSN - Luda | |
| Choi Seung-cheol | Musical Guest | Seventeen - S.Coups | |
| Kim Min-ju | Musical Guest | Iz*One - Minju | |
| Lee Chan | Musical Guest | Seventeen - Dino | |
| Seo Jung-kwon | Musical Guest | Tiger JK | |
| Shin Dong-Gab | Musical Guest | The Quiett | |
| Yoon Mi-rae | Musical Guest | Yoon Mi-rae | |
| Kim Jae-hwan | Musical Guest | Wanna One - Jaehwan | |
| Sung Ji-yeon | Musical Guest | Momoland - Jane | |
| j-hope | Musical Guest | BTS - J-hope | |
| Choi Young-jae | Musical Guest | Got7 - Youngjae | |
| Jeon Won-woo | Musical Guest | Seventeen - Wonwoo | |
| Nam Da-won | Musical Guest | WJSN - Dawon | |
| Jang Won-young | Musical Guest | Iz*One - Wonyoung | |
| Kim Mi-hyun | Musical Guest | Oh My Girl - Mimi | |
| Kang Hye-won | Musical Guest | Iz*One - Hyewon | |
| Ong Seong-wu | Musical Guest | Wanna One - Seongwu | |
| Hwang Min-hyun | Musical Guest | Wanna One - Minhyun | |
| Jackson Wang | Musical Guest | Got7 - Jackson | |
| Lee Hye-bin | Musical Guest | Momoland - Hyebin | |
| Ku Changmo | Musical Guest | Changmo | |
| BTS | Musical Guest | Intro + "Airplane Pt.2", "O!RUL8,2? Love Yourself Remix", "Idol" | |
| Lee Seok-min | Musical Guest | Seventeen - DK | |
| Nako Yabuki | Musical Guest | Iz*One - Nako | |
| Boo Seung-kwan | Musical Guest | Seventeen - Seungkwan | |
| WJSN | Musical Guest | "Save Me, Save You" | |
| Yoo Si-ah | Musical Guest | Oh My Girl - YooA | |
| Choi Seok-bae | Musical Guest | Nafla | |
| Ha Sung-woon | Musical Guest | Wanna One - Sungwoon | |
| Song Joong-ki | Host | Main host & presenter for Janet Jackson Inspiration Award | |
| Lee Yi-kyung | Guest Star | Presenter for Best Vocal Performance Solo | |
| Kim Sung-ryung | Guest Star | Presenter for Best Male Group | |
| Ahn Jae-hyun | Guest Star | Presenter for Best Male Artist and Best Dance Performance – Solo and Male Group | |
| So Yi-hyun | Guest Star | Presenter for New Asian Artist | |
| Kim Jong-kook | Guest Star | Presenter for Best Asian Artist (Mandarin) | |
| Jackson Wang | Guest Star | Presenter for Janet Jackson Inspiration Award | |
| Moon Ga-bi | Guest Star | Presenter for Best Vocal Performance Solo | |
| Angelababy | Guest Star | Presenter for Album of the Year (Daesang) | |
| Lee El | Guest Star | Presenter for Best Asian Style and Discovery of the Year | |
| Kwon Hyuk-soo | Guest Star | Presenter for Mwave Global Fan Choice | |
| Seo Hyun-jin | Guest Star | Presenter for Best Female Group | |
| Lee Dae-hwi | Guest Star | Presenter for Janet Jackson Inspiration Award | |
| Yoon Jong-bin | Guest Star | Presenter for Best OST | |
| Cha Seung-won | Guest Star | Presenter for Song of the Year (Daesang) | |
| Kim Sa-rang | Guest Star | Presenter for Best Male Artist and Best Dance Performance – Solo | |
| Bae Jung-Nam | Guest Star | Presenter for Mwave Global Fan Choice | |
| Kim Dong-wook | Guest Star | Presenter for Best Unit | |
| Jung Ryeo-won | Guest Star | Presenter for Best Dance Performance – Male Group | |
| RM | Guest Star | Presenter for Janet Jackson Inspiration Award | |
| Lee Sun-bin | Guest Star | Presenter for Best OST | |
| Hwang Jung-min | Guest Star | Presenter for Artist of the Year (Daesang) | |
| Lee Seung-chul | Guest Star | Presenter for TikTok Best Music Video | |
| Lee Jung-hyun | Guest Star | Presenter for Best Dance Performance – Female Group and TikTok Most Popular Artist | |
| Kim Da-mi | Guest Star | Presenter for Best Unit | |
| Lee Jin-uk | Guest Star | Presenter for Best Female Artist | |
| Park Sung-woong | Guest Star | Monologue for "Episode 17" Performance and presenter for Best Asian Style and Discovery of the Year | |
| In Gyo-jin | Guest Star | Presenter for New Asian Artist | |
| Lee Yo-won | Guest Star | Presenter for TikTok Best Music Video | |
| Seo Eun-soo | Guest Star | Presenter for Best Dance Performance – Female Group and TikTok Most Popular Artist |