重案Ⅵ组成员包括曾克强（李成儒饰）、季洁（王茜饰）、江汉（董勇饰）、白羚（高榕饰）和黄涛（张博饰），前三位在破案一线工作多年，后两位刚跨出警校大门。他们在局长（张潮）指示下，侦破了一起起凶杀、爆炸、投毒、绑架、抢劫、截肢等案件。但神勇冷面下，五人亦有柔情和心事。 曾克强某次侦案 时因迟来一步令队友被杀，发誓要抓到凶手却总不能如愿；季洁要与男友踏上红地毯前夕，发现他与妹妹有染；白羚和黄涛的侦案知识多来源于书本，实战经验的缺乏常令他们拖整队的后腿，而五人也因性情不一常有矛盾产生。但有案要侦时，五人又总能迅速调整状态，将缉凶视作第一。
| Season | From | To | Episodes |
|---|---|---|---|
| All Seasons | |||
| Specials | 0 | ||
| Season 1 | January 2001 | 32 | |
| Season 2 | January 2003 | 32 | |
| Season 3 | January 2009 | 36 | |
| Season 4 | January 2011 | 36 | |
| Unassigned Episodes | 27 |
| Season | From | To | Episodes |
|---|---|---|---|
| Unassigned Episodes | 163 |
| Season | From | To | Episodes |
|---|---|---|---|
| Season 1 | 0 | ||
| Unassigned Episodes | 163 |
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