Prepare to have your heartstrings pulled, because this episode opens in a pediatric cancer ward. Deputy Director Sam Cullen's young daughter, Amy, has mysteriously developed lung cancer after receiving a bone graft from a 60-year-old, instead of a much younger and healthier donor. Booth and Brennan chase down the reason and discover that Amy is not the only victim. Meanwhile, Angela grows closer to Amy, who wants to fall in love before she dies. Although Carla and Emily love the sweet moments, they wonder if things get a little too on the nose in other places. Also, they talk about Emily and David’s fun chemistry during their press tour.