Just before her 15th birthday, Princess Cleopatra is zapped 30,000 years into the future where she discovers that she is the prophesied savior of the galaxy.
Cleo tries to find her place at the Academy, unaware that Akila is planning a surprise birthday party for her.
Homesick, Cleo tries joining some school clubs to feel better; however, her homesickness has an unexpected and destructive effect.
Cleo's overconfidence gets her friends captured; to rescue them, she must convince a tribe of laid-back aliens she can master their high values of humility, serenity and caution.
When Brian and Cleo try to get Akila to say "no," they find themselves face to face with the galaxy's grossest outlaws -- the scavengers.
After a successful mission, Cleo spreads the flu to everyone on campus.
When Khepra threatens to split up Cleo, Akila and Brian, the trio must demonstrate that they make a great team.
Frustrated with life in the future, Cleo tries out Brian's untested time machine to return to ancient Egypt; in the process, she's caught in an ever-shrinking time loop that could destroy the entire universe.
Cleo is determined to prove Callie is the spy once and for all; meanwhile, Akila hires her favorite band for the academy's annual "No Science Fair."
Khensu tasks Cleo with mentoring a younger student named Philo, who turns out to be just as cocky and brash as she is; getting a taste of her own medicine, Cleo's respect for Khensu grows.
Posing as Pharaoh Yosira, Cleo tries to convince galactic leaders to join the fight against Octavian; at the same time, Cleo tries to uncover who is planning to kill Yosira.
While Cleo and the gang try to find Octavian's spy, a robot impersonates various people from the academy.
Cleo and her crew go on a rescue mission to crime-ridden Hykosis City, which leads to a devastating confrontation with Octavian.
After a mission, Cleo brings home an adorable ferret, as well as suspicious eggs that threaten the academy.
Cleo tries to figure out where the UTA Tablet is, Brian tries to ask Akila out on a date, and is too nervous to do so. In this situation, Brian turns to A.I. named Cyrano, thinking he will solve his social problems, making him cool.
After spending too much time together, the team splits up on an unknown planet to search for the Uta Tablet.
Brian and Akila go on their first date, and the ensuing chaos leads to Cleo going off on a mission alone.
Cleo comes to visit Akila's family during their school break.
Yosira joins the gang on a mission to the space station and factory, named Xerxs Works, where Xerxs are built. However, Cleo and Yosira disagree who will lead the assault on Xerxs Works.
Mihos gets parasites, causing him a serious illness, so Cleo and her friends shrink to a tiny size to help heal him. This adventure becomes stranger and weirder than any of them would have envisioned.
When all the other students at the Academy discover that Cleo is the 'Savior of the Galaxy' of prophecy, she thinks, and fears, she will be treated differently.
Khepra, head of the P.Y.R.A.M.I.D. council takes Callie, Akila, and Cleo out on a "girls night" to the arcade. Cleo dislikes it until Khepra starts quarrelling with a few of the guests.
Space pirates are proving to be more and more important. On one mission, Akila, Brian, and Cleo are captured by them, but the coolness of the pirates makes it hard to dislike them.
Brian and Akila fall into a trap, with Brian reprogamming a broken Xerx who becomes their baby. In order to save themselves, they need to educate this Xerxs robot quickly.
At long last, Zaid and Cleo find the UTA Tablet, but guards want Cleo to remain their queen. Cleo is tempted by the offer.
A big betrayal is revealed, with Octavian invading Mayet for real. The fate of the galaxy remains in the balance.
