When the lead actor of the musical “The Lion King” tour arrives at Angels Memorial with a throat infection, Leanne gives him a diagnosis that puts both his career and life in jeopardy. Also, the doctors and the cast of “The Lion King” help a 17-year-old boy deal with the difficult decision of taking his father off life support,
The ER adjusts to the new department head who questions Rorish's decisions. An ambulance arrives with its paramedics knocked out by their patient, who attacks Jesse. Later, Jesse has a heart attack. As the doctors try to save him, other patients include a man hit by a train, the daughter of a controlling Beverly Hills mother, and the wife of a veteran who is struggling with addiction. Meanwhile, Mario leaves the hospital to find the train victim's son with intellectual disabilities, against Hudson's orders.
Leanne, Neal, Christa, Angus, Mario, Malaya, and Heather are sent to the scene of a multi-car collision on a canyon road above Los Angeles. Leanne clashes with the physician in charge, making a decision he questions. Christa treats an injured family whose car is in a ravine. Angus, Heather, and Mario help a man stuck in cement. Mario and Heather find their lives in danger when a patient's husband holds them at gunpoint to save his wife. Meanwhile, Jesse recovers from his heart attack.
Christa becomes insecure in her new relationship with Neal when his ex-girlfriend, Dr. Grace Adams, returns to Angels Memorial after spending a year volunteering in Haiti. Also, New York Giants Pro Bowl wide receiver Odell Beckham Jr. comes to the ER to convince his stubborn high school football coach, Pete Delaney, to have life-saving surgery.
Willis defies Campbell’s orders when he helps Mario and Heather perform a radical procedure on a maintenance worker stuck under a boiler that exploded. Also, Angus’ father, Dr. Desmond Leighton, tries to seize Power of Attorney over Mike, who is still in a coma, even though Mike granted that right to his brother, Angus.
Malaya must inform a college student who regains consciousness at Angels Memorial that she's the victim of a rape. Meanwhile, Willis and Campbell butt heads over a terminally ill woman who wants to end her life on her own terms; and a comedian is treated after he collapses on stage during a performance.
A code black at Angels Memorial takes a turn for the worse when a city- wide blackout leaves the hospital without power or back-up generators. As Campbell and Leanne divert high-risk patients to a nearby care center, Elliot and Heather are trapped in an elevator with a woman in labor, and Willis and Dr. Nolan try to help a 92-year-old woman who thinks it’s 1942.
A drug bust-turned-shootout tests the bravery of the doctors of Angels Memorial as they race to save a girl caught in the crossfire. Also, Willis shifts his focus to field medicine, choosing to work primarily on an ambulance with his new partner, paramedic Rox. And Leanne begins her journey to adopt Ariel.
Angus and Mario treat a patient who is a self-proclaimed psychic and envisions the staff singing and dancing, seeing beauty amid the chaos at Angels Memorial. Also, Willis and Rox put their lives in danger to rescue a congressman and his staffer from a multi-car accident.
Jesse is in denial when his brother arrives at Angels Memorial in bad shape after being pinned down in a warehouse collapse and further tests reveal he has advanced congestive heart failure. Also, Willis opens up to Rox about his brother who was killed in Afghanistan.
Willis and Rox arrive at a road rage accident resulting in multiple serious injuries. Also, Elliot doubts his ability as a doctor when he’s sued for his role in the death of the SWAT officer involved in the drug bust-turned-shootout, and Leanne discovers Ariel on an ice cream “date” with Max, a young patient at the hospital.
Over the radio, Leanne and Jesse talk a young girl through how to use the supplies on board a small plane to build a makeshift defibrillator when her mom, the pilot, loses consciousness. Also, Rox and Willis are taken hostage at gunpoint while on their way to meet the plane at the landing site. Julitta Scheel, Marcia Gay Harden’s daughter, stars as Ruby Harris, the young girl on the plane.
Willis and Rox are called to the scene of a wildfire in the mountains of Los Angeles to tend to the injured firefighters and choose to stay to look for a missing young boy who was separated from his father in the chaos.
Rox decides to make amends with her former step coach when she arrives to Angels Memorial with the local high school step team after a pyramid stunt goes wrong. Also, Noa pleads with Leanne and Campbell to try any other method before performing an emergency hysterectomy on a young teenage girl experiencing complications after giving birth.
Mario joins Rox and Willis on the scene of a boat crash and, in Center Stage, Leanne works to save a brother and sister who drank boiling water through a straw as part of a challenge. Also, Max’s father tells Leanne to keep Ariel away from his son after he finds them kissing.
Max is brought to Angels Memorial with breathing difficulty and Ariel tells him she loves him. Also, Rox accompanies Willis and Martin to the funeral of an army buddy of Willis’ brother, and Willis decides to get to the bottom of what happened to his brother’s unit.
Elliot fears the worst after hearing the emotional testimony by Detective Gomez’s wife at his malpractice trial, but hopes footage Diego shot for his documentary will change her mind. Also, Rox attempts to connect with Willis but he pushes her away, and Leanne attempts to comfort Ariel in the wake of a devastating loss.
While rescuing an injured firefighter, Rox is hit by a drunk driver and rushed to Angels Memorial. Willis begins to realize his feelings for Rox and goes to great lengths to help her. Also, Leanne is excited to tell Ariel good news about her adoption.
Willis continues to tend to Rox’s medical needs in San Diego and Leanne and Max’s father go searching for Ariel. Also, when Noa reveals to Mario she wants to take a job offer in Philadelphia, and Campbell offers Mario the attending position at Angels, they realize their career choices will mean ending their relationship.
Angels Memorial descends into chaos when a plane crashes into the 8th floor. Also, Noa has a car accident and it is up to Mario to save her life. Also, Willis admits to Rox that he needs her in his life and the doctors gather in court to support Leanne for her custody hearing.