Drake and Josh both find out that Drake's Mom, and Josh's Dad, get married to each other unexpectedly. Drake finds it completely wrong. And Josh on the other hand is really excited. Right as Drake things his life is miserable, things get better. He discovers that Josh is actually Miss Nancy, a person who gives advice in the school newspaper. After reading one of Josh's Miss Nancy letters, Drake discovers that Tiffany (the girl he likes) is having trouble with her boyfriend. Drake uses this advantage to go on a date with her. But Tiffany's real boyfriend gets things confused, and thinks Josh is dating Tiffany! Now Josh must study to be excellent at karate before Tiffany's boyfriend scars him for life.
Susan, Drake's girlfriend flirts with Josh, constantly kissing him, but Susan is such a good liar that when Drake is around she makes Drake think Josh is hitting on her.
Drake and Josh have to babysit their Dad's boss's son. The baby disappears and Josh panics while Drake leaves to play in a concert. Drake comes back to help Josh, and finds out that Megan has had the baby the whole time.
Josh tries to impress his first crush Kathy, but gets so nervous he accidentally says he can play the guitar. Drake, meanwhile, gets kicked out of the restaurant his band played in (due to Megan's new snake.) Kathy asks Josh to play the guitar for her at her birthday party (which, coincidentally, happens to be at the same restaurant Drake got kicked out of), Drake and Josh work out a plan so that Josh can impress Kathy and Drake can get back into the restaurant, called the Brew Note. The guy who taught Josh karate owns the restaurant.
Drake and Josh's parents are going away for the weekend and Drake and Josh are excited because they think they can do what they want. But when Josh's Grammy comes to babysit Josh is enjoying it, but not so much Drake. Grammy won't let Drake out of the house to see a concert, so he sneaks out.
Josh gets grounded because of something Drake did. The boys later receive a broken dune buggy from Trevor, a friend of Drake's. In Josh's free time, he fixes the dune buggy. One day, Drake drives the dune buggy (against his parent's wishes, and without their knowledge), but he runs into a tree, getting several injuries. He hides his injuries from his family using makeup, but Josh soon finds out what had happened and blackmails him until he tells the truth.
Drake is so excited when Megan wins a radio contest, and the prize is tickets to the Zero Gravity concert and a guitar signed by Devan Malone, the head guitarist of Zero Gravity. The best part is, Megan lets Drake have the prize! Drake is so obsessed with this guitar. When Josh accidentally sets the guitar on fire, he must come up with a way to replace it before Drake becomes insane forever. Meanwhile, Walter tries to spend quality time with Drake, but everytime Walter tries to go for it, Drake is doing something important.
Drake and Josh make a bet to swear off junk food (Drake) and Video Games (Josh). Megan makes both of them swear to dye their hair pink (whoever loses). When Drake and Josh's mom and dad discover them making a bet, they make a bet as well. When things get crazy, Drake and Josh can't hold onto their bet much longer and decide to break it.
Josh and Drake both get a job at the movie theater. Josh does a bunch of work, but Drake slacks off and gets all the credit. When Drake becomes Josh's boss, Josh is fed up, because he was doing all of Drake's work for him.
Drake finds out Josh is great at pool or billiards as Josh calls it. Drake bets some kids, and takes advantage of Josh's pool skills and starts hustling people, by taking their money, shoes and other clothing/personal items. Now Josh has made the ultimate bet, and Drake's stuffed in the corner pocket.
Drake tries to make Josh cool by telling him to try out for the football team. Instead, Josh gets "murdered" and he ends up being equipment manager, which isn't cool. Later, when the one of the player gets sick by Josh's brownies, the coach depends on Josh to play center. So now Drake must help Josh become cool and at the same time not actually play.
Josh is confident about when Walter chooses him to be his co-weatherman. That is, until Megan reminds Josh of his uncontrolable twitch. So Josh twitches in front of the whole world and becomes the laughing stock of San Diego. Meanwhile, Drake is determined to win the talent show for the third year in a row but finds it challenging when he rivals with an acappella group.
Drake meets a smart girl from school named Michelle that he really likes. Now, Drake is not the smartest kid in school, so he gets Josh to teach him things to impress Michelle. But things go too far when he accidentally says yes to an offer of joining the Academic Team. Meanwhile, Josh has had enough with Megan's pranks and tries to get back at her.
Ashley Blake is coming to the movie theater for the premiere of her new movie. Helen wants Josh to do everything Ashley tells him. Then Drake helps him in order to get into the afterparty. When Ashley accidentally gets hit in the head with a bucket, the doctor comes and puts Ashley to sleep. Drake and Josh must find a way to get her to the premiere without making it look like she's asleep.
Walter is really excited when his two sons are getting their driver's licenses. He made a rule with his sons, if they get one traffic ticket, he'll take their license away. The problem is, Josh gets his license and Drake doesn't. So when Josh runs a stop sign and gets a ticket, Drake pays for the ticket and doesn't tell Walter. Drake uses this to his advantage and blackmails Josh into driving him to unnecessary places.
Drake has a girlfriend named Kelly who has a laughing problem. He really wants to break up with her, but can't. The reason why is because she is the daughter of Drake's mean teacher, Mrs. Hayfer, who threatens him with summer school if he breaks up with her daughter. Meanwhile, Josh gets a very ugly shirt which he claims as good luck.
An obsessed fan is in love with Drake. She loves him so much, she says she's going to marry him and won't leave Drake a moments peace. So Drake must get this #1 fan to stop embarrassing him and ruining his life. Meanwhile, Josh becomes the new chief of the campfire kids but finds it tricky to deal with kids.
Drake & Josh are approached by two salesmen who offer them a one-time deal, Gary Grills. Drake and Josh quickly become attached to them and sell them acceptionally. But they don't realize that these Grills come with a price.
Drake is getting tired of hanging around with Josh all the time. So Josh finds a friend named Drew who looks just like Drake. Drake feels he is being left out because of Drew, so he finds his own friend named Jerry who looks and acts like Josh.
Drake is accused of parking Mrs. Hafer's car in the middle of her classroom. Drake and Josh must go in front of the school's Honor Council to prove Drake is innocent.
Drake and Josh enter a salsa contest so they can win a 45 inch high depth Yatzubishi plasma screen TV. But they won't let Megan join their team, so she decides to play dirty. After she gets the boys in trouble twice and she makes her own salsa, she buys the ultimate target for Drake and Josh. The Peruvian Puff Pepper.
Josh's e-pal, Yooka, is coming from Yudonia to visit Josh. Drake doesn't care about her at first, but then he sees how hot she is. Josh overhears Yooka telling her parents she is homesick, so he arranges what he thinks is a friendship ceremony but is really a marriage ceremony.
It's the time for the Science Fair. Josh is confident that he'll win first prize, until Mindy Crenshaw returns! Josh comes in second like every year, but he turns out to have a change of heart. After the Science Fair, he develops a liking of Mindy who also has a liking of him. Right before they know it, they're boyfriend and girlfriend!
When Walter is always coming home late and talking to another woman, Drake and Josh believe Walter is cheating on Audrey and they start snooping. Drake and Josh try all types of plans to keep them together.
When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.
Drake's "friend" Tori, who he has been dating for a while, calls him her boyfriend. Drake breaks up with her, because he thinks they both should see new people. Meanwhile, Josh grows a mustache and is determined to make Mindy kiss him again.
After Helen has eye surgery she asks Drake and Josh to help her around her house. When Drake sees that she has a hot tub, a plasma screen TV, and a dancing machine, he takes advantage of Helen's blindness to use all her cool stuff.
When Drake and Josh remember they got in a fight several years ago at a San Diego Padres game, they realize they fought each other. Then they spend the next few days fighting over who started the fight.
When Josh recieves a foot injury, his parents take him to the hospital. While at the hospital, Drake poses as a doctor to impress a bunch of nurses. Then another doctor comes in and thinks he is a famous doctor. Because of this, he has to perform a foot surgery. How can Drake escape without being revealed of breaking the law?
Megan buys a pregnant sheep and makes Drake and Josh take care of it, if Megan Promises to not pull any pranks on Drake and Josh for awhile. But when they see what a pregnant sheep can do, they don't want it much anymore.
Mindy invites Josh over to her house for dinner and to meet her parents, but things don't go well. Josh hosts another dinner at his house to try and impress Mindy's parents to make up for last time. He asks Drake to not mess up his date. Meanwhile Drake and his new girlfriend, Lucy, wrestle to see who is tougher, to prove that some girls are tougher than boys.
With their parents out of town and Megan planning a trip to Denver, Drake and Josh find they'll have the house to themselves for the week. But when they mistakenly put Megan on the wrong flight, they have to take the next plane to Los Angeles to find her.
To keep from being sent to remedial English, Drake agrees to mentor a little kid named Sammy. Unfortunately, Sammy would rather hang out with Josh.
Josh nabs a student teaching job in Megan’s classroom where Drake discovers an amazing kid drummer. But when the class revolts against teen taskmaster Josh, Drake rushes in to help Megan discredit him -- perchance to snare the drummer for his band.
Josh gets a part on a TV crime show where he plays the infamous "Theater Thug." Following his TV debut he becomes a public enemy as a case of mistaken identity gets out of hand.
A new roller coaster is coming out called, the Demonator. Drake and Josh want to be there the first day it opens. But when they get in line, their wild adventure starts.
Drake and Josh decide to turn the tables and prank little Megan. She actually believes that aliens are coming down to Earth and they are going to kidnap her. But at the end, Drake and Josh find that this may not go as they hoped.
Drake and Josh go on the Dr. Phyliss Show and relive some of their most outlandish moments. Some will jab at your funny bone, while others will tug on your heart strings.
Drake and Josh accidentally kill Megan's hamster and they think she is planning revenge.
Mrs. Hayfer needs a house sitter for the weekend and it's the boys to the rescue, but all doesn't go according to plan when they meet Tiberius, a vicious dog with an appetite for… Drake and Josh?! Walter is exercising for the mile run against another weather man.
Mindy tells Josh that she loves him and Josh slams the door in her face and runs to Drake, but Drake tells Josh that she is just trying to distract him so she can win the Science Fair.
Drake and Josh meet, "The Great Doheny", and find out that he relies on his new friends a little too much because he has lost everything including his career. In an attempt to get his career back for him, Drake and Josh find themselves in a tough situation.
Josh is jazzed at the prospect of meeting his TV idol when Drake gets tickets to “Oprah” for his birthday, but delight turns to dismay in the studio parking lot.
The boys are tired of sharing a ride and get money to buy a car, but all goes bananas when Drake buys an orangutan named Bobo instead. Soon they think they can make some money off their new friend, but things get hairy when they find out the man who purchased him may be an evil Doctor with unique.
Drake and Josh enter a "Pump My Room" contest to try and redecorate the living room as an anniversary gift for their parents. When they come back to the house they realize that everything is gone. To get the furniture and everything else back, Drake and Josh get a job at a sushi factory, but come home to see that everything is back.
Drake, Josh, and Megan must rebuild a tree house that they accidentally destroyed
Drake teases Josh that he can't get girls. So, Drake and Josh make a bet to see how many girls each of them can date in just one week. The rules are, every date must last at least one hour, you can't date someone you already know, and you can't date the same person twice.
Drake wins a free skydive off a helicopter and sets off to do it despite his parents' wishes. Josh, being the good brother he is, tries to stop him, but ends up going along for the ride. This fun time in the sky becomes a true downer when they accidentally lose their pilot and things start spinning out of control.
The whole gang has gathered at Drake and Josh's house before Drake's big concert, but thanks to Walter's poor weather predictions they end up stuck in the house due to severe rain. Sure, it's raining outside, but the real storm for Drake to weather is when his new girlfriend meets his exes.
Drake and Josh are on their way to a family wedding in their car. Unexpectedly and in the middle of nowhere, the car breaks down. This wouldn't be much of a problem, if it weren't for the fact that they're the ones bringing the cake to the reception.
Josh decides to enter a local dance contest, but when Drake realizes he's going to fail gym, he has to enter in order to receive high school credit. So he steals Josh's dance partner, and that's when things start to go wrong.
After the boys get in trouble for using Fake ID's Audrey and Walter fear they will fall to a life of crime and sign them up for a “Steered Straight” program, but things start skidding out-of-control when a real criminal befriends them.
Drake has taken advantage of Josh for the last time and Josh decides that he is done dealing with Drake. Drake says he's fine with this, but when Josh's life improves and Drake's goes down the drain this rocker begins crooning a different tune.
The most popular kid in school is throwing what may be the greatest sixteenth party ever, but Drake and Josh may be having cake for two after they get banned from the party.
After accidentally punching Drake in school, Eric becomes very popular. Meanwhile, Josh thinks that Mindy has a new boyfriend.
Megan's been extremely secretive and Drake and Josh investigate to find out what she's up to. The clues lead to a new boyfriend and all seems wonderful until they find out Megan's new beau may be trouble.
Drake gets a music deal to perform a song for a commercial, but Josh manages to screw it up by signing over creative control. Meanwhile, Helen, without warning, names Mindy assistant manager as she prepares for her wedding, upsetting Josh, who has wanted the job for a long time.
Drake finally lands a record deal with Spin City Records with Josh as his manager. Everything seems to be going well, until Josh is convinced to sign an unread contract, for which he calls Drake's song an unwanted pop song, so Drake fires Josh. Josh gives the news girl the disc of the original song (the one that wasn't the pop mix). Also, Mindy gets a job at The Premiere to be closer to Josh, which doesn't work. Helen's wedding is coming up and Helen wants Craig and Eric to videotape their wedding. Helen's grandmother is staying at the Parker-Nichols family home for the day of their wedding, so Megan sleeps in Drake and Josh's room.
While working at the mall as Santa Claus and his assistant, Drake and Josh meet a less-fortunate girl and make her a promise that this will be the best Christmas ever.
