| Name | First Aired | Runtime | Image | |
|---|---|---|---|---|
| S10E01 | Lottery Fever | September 25, 2011 | 20 | |
| S10E02 | Seahorse Seashell Party | October 2, 2011 | 20 | |
| S10E03 | Screams of Silence: The Story of Brenda Q | October 30, 2011 | 20 | |
| S10E04 | Stewie Goes for a Drive | November 6, 2011 | 20 | |
| S10E05 | Back to the Pilot | November 13, 2011 | 20 | |
| S10E06 | Thanksgiving | November 20, 2011 | 20 | |
| S10E07 | Amish Guy | November 27, 2011 | 20 | |
| S10E08 | Cool Hand Peter | December 4, 2011 | 20 | |
| S10E09 | Grumpy Old Man | December 11, 2011 | 20 | |
| S10E10 | Meg and Quagmire | January 8, 2012 | 20 | |
| S10E11 | The Blind Side | January 15, 2012 | 20 | |
| S10E12 | Livin' on a Prayer | January 29, 2012 | 20 | |
| S10E13 | Tom Tucker: The Man and His Dream | February 12, 2012 | 20 | |
| S10E14 | Be Careful What You Fish For | February 19, 2012 | 20 | |
| S10E15 | Burning Down the Bayit | March 4, 2012 | 20 | |
| S10E16 | Killer Queen | March 11, 2012 | 20 | |
| S10E17 | Forget-Me-Not | March 18, 2012 | 20 | |
| S10E18 | You Can't Do That on Television, Peter | April 1, 2012 | 20 | |
| S10E19 | Mr. & Mrs. Stewie | April 29, 2012 | 20 | |
| S10E20 | Leggo My Meg-O | May 6, 2012 | 20 | |
| S10E21 | Tea Peter | May 13, 2012 | 20 | |
| S10E22 | Viewer Mail #2 | May 20, 2012 | 20 | |
| S10E23 | Internal Affairs | May 20, 2012 | 20 |
