| Name | First Aired | Runtime | Image | |
|---|---|---|---|---|
| S04E01 | North by North Quahog | May 1, 2005 | 20 | |
| S04E02 | Fast Times at Buddy Cianci Jr. High | May 8, 2005 | 20 | |
| S04E03 | Blind Ambition | May 15, 2005 | 20 | |
| S04E04 | Don't Make Me Over | June 5, 2005 | 20 | |
| S04E05 | The Cleveland-Loretta Quagmire | June 12, 2005 | 20 | |
| S04E06 | Petarded | June 19, 2005 | 20 | |
| S04E07 | Brian, The Bachelor | June 26, 2005 | 20 | |
| S04E08 | 8 Simple Rules for Buying my Teenage Daughter | July 10, 2005 | 20 | |
| S04E09 | Breaking Out Is Hard To Do | July 17, 2005 | 20 | |
| S04E10 | Model Misbehavior | July 24, 2005 | 20 | |
| S04E11 | Peter's Got Woods | September 11, 2005 | 20 | |
| S04E12 | Perfect Castaway | September 18, 2005 | 20 | |
| S04E13 | Jungle Love | September 25, 2005 | 20 | |
| S04E14 | PTV | November 6, 2005 | 20 | |
| S04E15 | Brian Goes Back to College | November 13, 2005 | 20 | |
| S04E16 | The Courtship of Stewie's Father | November 20, 2005 | 20 | |
| S04E17 | The Fat Guy Strangler | November 27, 2005 | 20 | |
| S04E18 | The Father, The Son, and The Holy Fonz | December 18, 2005 | 20 | |
| S04E19 | Brian Sings and Swings | January 8, 2006 | 20 | |
| S04E20 | Patriot Games | January 29, 2006 | 20 | |
| S04E21 | I Take Thee Quagmire | March 12, 2006 | 20 | |
| S04E22 | Sibling Rivalry | March 26, 2006 | 20 | |
| S04E23 | Deep Throats | April 9, 2006 | 20 | |
| S04E24 | Peterotica | April 23, 2006 | 20 | |
| S04E25 | You May Now Kiss The...Uh...Guy Who Receives | April 30, 2006 | 20 | |
| S04E26 | Petergeist | May 7, 2006 | 20 | |
| S04E27 | The Griffin Family History | May 14, 2006 | 20 | |
| S04E28 | Stewie B. Goode | May 21, 2006 | 20 | |
| S04E29 | Bango Was His Name-O | May 21, 2006 | 20 | |
| S04E30 | Stu & Stewie's Excellent Adventure | May 21, 2006 | 20 |
