The fourth season of High Stakes Poker starts with Phil Hellmuth, Haralabos Voulgaris, Antonio Esfandiari, Tony Salorio, Mike Matusow, Phil Laak, Brian Brandon, and Todd Brunson playing $300/$600 No-Limit Hold'em.
| Name | Type | Role | |
|---|---|---|---|
| Gabe Kaplan | Host | Himself - Commentator | |
| A.J. Benza | Host | Himself - Commentator | |
| Phil Hellmuth | Guest Star | ||
| Todd Brunson | Guest Star | ||
| Mike Matusow | Guest Star | ||
| Haralabos Voulgaris | Guest Star | ||
| Phil Laak | Guest Star | ||
| Antonio Esfandiari | Guest Star | ||
| Brian Brandon | Guest Star | ||
| Antonio Salorio | Guest Star |