Matt and Natalie are young teachers who rarely get to travel anywhere aside from school trips. Additionally, Natalie and her sister, Leslie, haven't had a chance to travel together since they were kids, so a trip with her and her boyfriend, Alvie, is a dream come true. House Hunters on Vacation is sending them to picturesque Santa Fe, New Mexico, where they will be choosing between three fabulous rental homes to spend a week in while exploring the Land of Enchantment.