Professor Brian Cox guides viewers through 350 years of British science to reveal what science really is, who the people are who practise it, and how it is inextricably linked to the past, present and future of each and every one of us. British science has a long track record of accidental discoveries improving our lot. Wondering why the sky is blue helped British scientists crack bacterial infection, whilst looking for a way to make quinine helped make our world a much more colourful place, as it led to the discovery of the first synthetic organic dye. But is this the best way to carry on? Professor Brian Cox ends his homage to British science by looking at how discoveries are made, asking whether it is better to let the scientists do their own thing, and hope for happy accidents, or to only back scientific winners at the risk of missing the occasional gems.