Jin returns to Edo from Nagasaki in disagreement with Ryoma. At that moment, Kyotaro, who has been ordered by his superior to investigate all matters related to Ryoma, visits Jinyudo repeatedly in order to probe.
Jin tries once again to recall when Ryoma was assassinated but cannot remember accurately. Then he is overcome by a headache once again.
At that moment, a letter addressed to Jin and Saki from Nokaze is delivered. She is to be legally married to Lelong and would like the two of them to come for the wedding ceremony. So Jin and Saki head to Yokohama to attend the wedding, but when they arrive down there, they are told by Nokaze that there is a patient who needs to be examined.
南方仁（大沢たかお）は、坂本龍馬（内野聖陽）と気持ちがすれ違ったまま、長崎から江戸・仁友堂に戻る。一方で、龍馬に関する事を探るように上役（中原丈雄）から命じられた橘恭太郎（小出恵介）は、探りを入れるため、「仁友堂」を訪れていた。あらためて「龍馬暗殺」がいつだったか思い出そうとする仁だったが、正確に思い出せないでいたが、またしても頭痛が仁を襲う。
橘恭太郎奉命偵查坂本龍馬週遭事情，而頻繁造訪「仁友堂」。南方仁努力回想龍馬到底是什麼時候遭到暗殺，卻怎樣也記不起來，而且感到激烈的頭痛。
就在此時，野風寫了一封信給仁與小咲，希望他們來參加婚禮...
