Joey has struck out on his own and moved to Hollywood, hoping to truly make it as an actor. Joey says goodbye to a time when his friends were his family and welcomes the chance to turn his family into his friends. After reuniting with his high-strung sister Gina, a strong and sexy hairdresser, Joey moves in with her genius 20-year-old son, graduate student Michael, who literally is a rocket scientist. What Joey lacks in book smarts, however, he more than makes up for with his people skills, making him the best new friend his nephew could ask for.
Over the course of ten years, six twenty-somethings living in New York — girl's girl Rachel Green, her on-again off-again flame Ross Geller, type-A Monica Geller, actor and ladies man Joey Tribbiani, sarcastic Chandler Bing and free spirit Phoebe Buffay — experience romance, fights, laughs, tears, and surprises as they learn what it really means to be a friend.