A rivalry of sorts develops between Race and Dr. Quest when the latter builds a computer pilot and Race believes nothing can outfly a human. But during a test flight Race is kidnapped by a former rival from his past, a man badly injured and using robotics to replace his missing body parts (thus the name ""Skyborg""). Skyborg is out to steal Quest's computer guidance system on behalf of the foreign power that gave him his parts.
The evil Dr. Zin has genetically modified household pests into disturbingly large insects that he calls assassinoids, fearless and devoted warriors that will carry out his plan for world domination. Team Quest, headed by internationally respected scientist Benton Quest, is Earth's only hope. When the good doctor becomes Zin's captive, the stakes - and the action quotient - grow higher. Enter Jonny Quest, Dr. Quest's bright, excitable, imaginative and heroic young son, ex-special agent Race Bannon, Jonny's child genius pals Hadji and Jessie (Race's daughter), their robotic pal 4-DAC and bulldog Bandit to complete the job of vermin extermination before it's too late. Your quest for colorful animated excitement ends here with this high-tech feature-length adventure based on the beloved Hanna-Barbera series.