The 13th Annual Nickelodeon Kids' Choice Awards was held on April 15, 2000, at the Hollywood Bowl in Los Angeles, live on Nickelodeon, with around 17,000 in attendance at the venue. Over 15 million voters cast ballots for the ceremony, including for ten online-only categories. Hosted by: LL Cool J, Rosie O'Donnell, David Arquette, Mandy Moore & Frankie Muniz
| Name | Type | Role | |
|---|---|---|---|
| Rosie O'Donnell | Host | Herself | |
| David Arquette | Host | Himself | |
| LL Cool J | Host | Himself | |
| Mandy Moore | Host | Herself | |
| Frankie Muniz | Host | Himself |