Fallon bids farewell to NBC's Late Night. Guests Andy Samberg and The Muppet's help the presenter bid farewell. Fallon kicks off the hour joining Buckwheat Zydeco on their song "On A Night Like This" Fallon wraps the show seated behind a drum set, where he performs "The Weight" by The Band alongside a fully-stacked cast of Muppets. Jimmy will be stepping into Jay Leno's shoes February 17, while other Saturday Night Live star Seth Meyer will take over Late Night February 24.
| Name | Type | Role | |
|---|---|---|---|
| Carmen Osbahr | Guest Star | Supporting Muppet Performer | |
| The Muppets | Guest Star | Self | |
| Stephanie D'Abruzzo | Guest Star | Supporting Muppet Performer | |
| Noel MacNeal | Guest Star | Supporting Muppet Performer | |
| Matt Vogel | Guest Star | Floyd Pepper / Camilla / Robin | |
| Paul McGinnis | Guest Star | Supporting Muppet Performer | |
| Brian Henson | Guest Star | Supporting Muppet Performer | |
| Andy Samberg | Guest Star | Self | |
| Ryan Dillon | Guest Star | Supporting Muppet Performer | |
| Martin P. Robinson | Guest Star | Supporting Muppet Performer | |
| Eric Jacobson | Guest Star | Miss Piggy / Fozzie / Animal | |
| Haley Jenkins | Guest Star | Supporting Muppet Performer | |
| Jennifer Barnhart | Guest Star | Supporting Muppet Performer | |
| Dave Goelz | Guest Star | Gonzo / Dr. Bunsen / Waldorf / Zoot | |
| Tyler Bunch | Guest Star | Supporting Muppet Performer | |
| Joey Mazzarino | Guest Star | Supporting Muppet Performer | |
| David Rudman | Guest Star | Scooter / Janice | |
| James J. Kroupa | Guest Star | Supporting Muppet Performer | |
| Alice Dinnean | Guest Star | Supporting Muppet Performer | |
| Steve Whitmire | Guest Star | Kermit / Beaker / Statler / Rizzo / Lips | |
| Julianne Buescher | Guest Star | Supporting Muppet Performer | |
| Peter Linz | Guest Star | Walter | |
| Lisa Buckley | Guest Star | Supporting Muppet Performer | |
| Pam Arciero | Guest Star | Supporting Muppet Performer | |
| Bill Barretta | Guest Star | Pepe / Dr. Teeth / Swedish Chef |