Megamind's former villain team, The Doom Syndicate, has returned. Our newly crowned blue hero must now keep up evil appearances until he can assemble his friends to stop his former evil teammates from launching Metro City to the Moon.
Megamind tries to win over the citizens of Metro City but finds his popularity tested when a new social media-savvy hero, Dude Monkey, arrives on the scene.
After Megamind causes an accident that makes Mr. Donut lose his memory, he convinces himself that the loveable shop owner is on the verge of turning evil and vows to stop him before he becomes a supervillain.
When Chum accidentally sprays a roach with an experimental intelligence substance that causes it to become a super genius, Megamind, Keiko and Chum must get rid of the spray and contain the roaches before they take over the city.
When Megamind's body-switching tech causes him and Roxanne to swap bodies, they must figure out how to act as the other before unleashing too much chaos and destruction on the city.
Roxanne's rekindled friendship with an old camp buddy makes Megamind jealous, so he reprograms Keiko's robot science project to act as his new best friend.
Chum clones himself to get everything accomplished and take care of an ill Megamind; when the clone makes additional copies of himself, things get out of hand.
Megamind refuses to teach Keiko how to be a hero, so she takes it upon herself to go undercover in the Doom Syndicate to prove herself.
Megamind's confidence is tested when Machiavillain finally reveals himself to the blue hero and puts him through a series of challenges to save the city from destruction.
Now considered a villain, Megamind must make his way through the city without being spotted.
In an effort to keep tabs on Metro City, Megamind goes undercover as an ordinary sales clerk.
Unbeknownst to Megamind, Machiavillain traps him in a video game-like virtual reality simulation.
When Machiavillain's schemes land Megamind in jail, he tries to find a way out.
When Megamind has trouble with a new villain, Destruction Worker, he goes to Music Man for help.
Megamind, Chum and the team attempt to infiltrate a festival thrown by Machiavillan to expose him.
When Machiavillain mind-controls the citizens of Metro City, Megamind and Keiko must find a cure.
Megamind faces the ultimate challenge when he must square off against an evil Roxanne.
