Zack Underwood, a new kid in town, meets Milo Murphy, the unluckiest kid in town. Because of Milo's misfortune, he and Zack both miss the bus for school, so Milo shows Zack a "shortcut" to school, while attempting to avoid wolves, bees, fire, and even an alien abduction. Meanwhile, Melissa Chase, a friend of Milo's, collects lunches as wagers from other students on whether or not Milo and Zack will make it to school before the bell rings.
Milo, Zack, and Melissa's subway car gets derailed on their way to a field trip to the museum. While trying to find their way to the museum, they encounter a society of construction workers who have been underground for a long time.
Milo, Melissa, and Zack try to protect an egg for a science experiment.
Milo attends his high school's football game, which turns into an extraordinary, explosive sporting event.
Milo and the gang spend the entire day chasing after his doctor's note.
Sara wants to see The Doctor Zone Files movie with Milo, but worries about potential problems.
Melissa and Zack organize a surprise birthday party for Milo, which can be a risky endeavor.
Milo, Melissa, and Zack go with their classmate Amanda to an opera concert for extra school credit.
It's career day and Milo is having a hard time deciding what his career should be. He tries to decide while visiting the water works, fire department, and hospital. But of course, everything goes wrong. Meanwhile, Dakota and Cavendish try and make sure a shipment truck full of pistachios make it to the pistachio warehouse.
Milo and his friends visit a dude ranch. While horse back riding, they meet a girl named Jackie who joins their posse, and Zack is smitten with love. But, Jackie leads them into more danger than usual. Meanwhile, Sara is going crazy because the ranch reminds her of scenes from The Doctor Zone Files, and invites other fans to join in the geek fest.
Milo and Zack try to help Melissa overcome her secret fear of roller coasters.
Milo accidentally vacations with the wrong family.
Milo and Melissa share their most embarrassing stories, but Zack refuses.
The gang participates in a school event that combines the Academic Decathlon and the Athletic Decathlon.
Milo's science class deals with a bored substitute. Meanwhile, Cavendish and Dakota hide in the classroom's closet to hide a substance that will help pistachios grow.
Milo and Zack go fishing with their dads. Meanwhile, when their phone battery dies, Cavendish and Dakota interfere with Brick and Savannah's time travel mission.
At a donation drive, Milo accidentally gives away his mother's precious vintage T-shirts. Cavendish and Dakota are assigned to protect the pistachios at the zoo.
Amanda does everything she can to make sure the school dance goes off without a hitch. Cavendish and Dakota go to the dance to attempt to prove without a doubt that Milo is another agent attempting to thwart their plans. Mort mistakes Cavendish and Dakota for vampire hunters.
Milo, Melissa, Zack, and Mort's band enters the battle of the bands. Zack discovers his old boy band is competing in the battle.
Milo, Zack and Melissa go to school after sunset to retrieve Melissa's math book. Unfortunately, she leaves the spare key inside the locked classroom, so the three go on a "quest" in search of the mysterious janitor, otherwise known as the "key-keeper".
When Melissa’s dad drives her and Milo into town on a decommissioned old fire engine, chaos ensues.
Milo and Melissa finally tell Zack the story of the infamous Llama Incident.
When Cavendish and Dakota stop Milo from destroying a pistachio plant, they change the future. Pistachio plants become sentient and take over the planet, so Cavendish, Dakota and Milo must race through time to save the future.
Elliot Decker is put in charge as the school's head safety monitor.
Milo learns that his favorite actor is supposed to be currently shooting a film nearby in town and decides to travel to the set and get his autograph.
Milo, Zack and Melissa set out in search of a missing robot that previously escaped.
Milo begins to sleepwalk through some nearby woods. Meanwhile, Cavendish and Dakota have a "ditch day" from pistachio duties after the ordeal from the evil pistachio creatures.
The students embark on a special trip while using the school's yacht.
During a Back to School Night event, the parents suddenly become children, thanks to Dakota's stolen time device.
Milo participates in a race and relies on Melissa and Zack to throw him reinforcements from his backpack to finish it. Meanwhile, Cavendish and Dakota, while attempting to stop the re-assigned Brick and Savannah from saving the pistachios, find themselves in the Old West and meeting Milo's great-great grandfather, Sheriff Murphy.
One morning, Elliot wakes up to discover that Milo has been erased. At first, he is naturally overjoyed, but soon becomes bored.
Cavendish keeps dying and Dakota repeatedly makes time paradox duplicate versions of himself to save him. Milo, Zack, and Melissa go to see Hamosaur 2, but Milo can't find his shoes.
Sara contemplates whether or not she's on a date with Neal from the comic book store. Milo, Zack, Melissa and Mr. Murphy go to the skiing slope, but the former three's toboggan goes out of control.
Milo, Cavendish, and Dakota travel to 1965 to help Orton Mahlson create The Doctor Zone Files. Unfortunately, they find that Derek, the son of King Pistashion, has somehow survived and has body snatched pretty much everyone, even in the present. In a cliffhanger, it turns out their sole hope lies in a particularly incompetent pharmacist.
Milo builds his own haunted house out of a decommissioned old truck and invites his friends to the fright fest, but Zack is not too amused because he's grown out of being scared on halloween, but thanks to Murphy's Law and the truck going on a wild ride throughout town, Zack slowly changes his mind. Meanwhile Dakota and Cavendish take in on the halloween fun while also investigating the mystery of the last halloween, which not surprisingly happens because of them, actually Dakota, and a wayward time grenade.
Sara, Milo, Melissa and Zack bring the Murphy family together for Christmas. Meanwhile, in the future, an older Cavendish and Dakota attempt to repair their broken friendship.
Milo and his friends meet up with Phineas, Ferb, and their Danville friends to try to stop Derek and his Pistachions from taking over the world.
Scott the Undergrounder gets a date with Milo’s science teacher, Miss Murawski.
Milo and Zack encounter dangerous, snow-related obstacles on their way to school.
It’s Picture Day at school and Milo can’t seem to get a single good portrait.
Diogee is mistaken for a secret agent.
Milo, Melissa, and Zack try to finish playing a board game for the first time in Milo’s life.
When there’s a big charity stock car race in town, Murphy’s Law wreaks havoc.
Amanda and Milo are chosen to compete on a kids’ extreme baking TV show. Will Murphy’s Law ruin Amanda’s lifelong dream of winning the competition?
Milo convinces Tobias Trollhammer to dress up as a woman in his newest Krillhunter movie.
Sarah gets annoyed by Doofenshmirtz spending all his time at the Murphy house and wants him to get out and do more.
Milo’s parents have one last chance to fulfill their dream of becoming Disco Dance Champions on roller skates before the skating rink closes down.
Milo and his friends try to save the old clock at City Hall that Melissa’s great-grandmother designed.
Amanda decides to become the manager of Milo’s band, and helps the foursome prepare for a concert in the park.
Doofenshmirtz wants to learn how to be good and shadows Milo for an entire day.
Aliens try to get the DNA of a sick Milo while Diogee works hard to prevent it.
Milo and the gang volunteer to help Zack with farm chores to prove he’s not a city boy.
Melissa enters a mentoring program with weather agent Savannah.
Milo, Zach, and Melissa try indoor skydiving.
Milo’s friends discuss their theories about what is really happening in Milo’s World.
Elliot is injured and hospitalized, so Milo substitutes for his side job as dog walker.
Milo takes a trip to the woods with his dad and grandfather in order to become a true Murphy.
Aliens from Octalia abduct Milo and are beset with problems. Melissa, Zack, and Doofenshmirtz notice Milo is missing and try to find him.
Milo and the gang try to save his Mom’s last goulash from getting ruined by Murphy’s Law.
Diogee becomes involved in intrigue when he eats a jump drive.
Doofenshmirtz becomes adventure buddies with Scott the Undergrounder.
While Milo tries to get inside the school to receive an award at an awards show his school is hosting, Diogee teams up with the police to catch Zippy, the world’s fastest koala.
All the guests at Zack’s surprise party are wearing casts, but their freak accidents apparently have nothing to do with Murphy’s Law.
Cavendish finds a crashed UFO.
Milo and Elliot accidentally get handcuffed together.
Cavendish mistakenly unleashes a giant alien.
Six-year-olds Milo and Melissa meet for the first time and Murphy’s Law makes their first day of kindergarten a big adventure.
Zack and Milo join Melissa’s new athletically minded wrestling, speech, and debate team.
Milo, Melissa, Zack, Mort, Amanda, and Bradley are stuck in detention for the afternoon.
Milo and the gang volunteer at the local park.
Doof and Dakota attempt to use a bizarre Cavendish-platypus hybrid to lead them to Dakota’s missing partner and friend.
Milo is abducted by aliens.
Milo faces down a cosmic storm made of Murphy’s Law while his friends work their way through the alien populace to save him.
