The Smiths poses as ""Spin Doctors"" for a New Orleans senator who's involved in a scandal where his girlfriend is accused of selling defense secrets to Iraq. Together with Rox they are trying to expose the real culprit.
The Smiths and a CIA-agent lose a ball of Plutonium-239 due to the interference of Bob Myers, an old friend of Jerry Rawlins (Mr. Smith). Now they must retrieve the Plutonium and protect Bob from the terrorist.
Mr. Smith disappears during a mission and leaves Mrs. Smith hanging. She escapes and begins to search for the missing Mr. Smith. Meanwhile, he finds out that his son has been kidnapped and to get him back he must kill a man.