It's a day of firsts for Blake who has just left Paramedic College and is now stationed in Coffs Harbour, NSW. His shift begins when a 13 year-old girl, worried about her mum, rings triple zero for an ambulance. The patient is suffering from severe respiratory distress complicated with a rare case of Swine Flu. It's a precarious situation and one that puts young Blake to the test. Saturday nights in Sydney are never quiet for a Paramedic. Trainee Rebecca and her mentor Chris are called to the aid of a young girl who is left collapsed and vulnerable on the side of a busy road. Her story rings alarm bells of a spiked drink. As more and more people drive into the city to paint the town red, probationer John is called to a five-car pile up on a major highway. His thoughts drift back to his first motor vehicle accident when he wasn't so sure on his feet.