Big Mama turns New York City into her new Battle Nexus arena and the TMNT have to fight to save everyone they love.
| Name | Type | Role | |
|---|---|---|---|
| Dale Malinowski | Writer | ||
| Vladimir Radev | Producer | ||
| Zelda Williams | Guest Star | Foot Recruit, Sprite | |
| Eugene Byrd | Guest Star | Cortex | |
| Jason Mantzoukas | Guest Star | Carl Sando | |
| Rhys Darby | Guest Star | Hypno-Potamus | |
| Johnny Rotten | Guest Star | Meat Sweats | |
| Kat Graham | Guest Star | April O'Neil | |
| Roger Craig Smith | Guest Star | Baron Draxum | |
| Jorge Gutiérrez | Guest Star | Ghostbear | |
| Thurop Van Orman | Guest Star | Todd Capybara | |
| Eric Bauza | Guest Star | Splinter | |
| Lena Headey | Guest Star | Big Mama | |
| Andy Suriano | Executive Producer | ||
| Ant Ward | Executive Producer | ||
| Kevin Molina-Ortiz | Director | ||
| Alan Wan | Director |