When magic makes its way from Witch World into the human world, Sabrina must protect her best friend, Harvey, who is forever changed by it as he is turned into a savagely violent werewolf every full moon.
Enchantra puts a dark curse on the red roses Sabrina brings to school to give to her human friends on Valentine's Day. With Veralupa's help, Sabrina must gather all of the snarling fanged roses to keep her human friends safe from being eaten alive.
When Sabrina has both a school play and a witch battle with her and her cousin Ambrose against an Ice Giant on the same night, her friendship with Jessie - the only human that knows that she is a witch - is put to the test; especially with Enchantra's arrogant son, Shinji, running interference during the battle.
Sabrina is in charge of finding a band for a benefit concert in Greendale, but Shinji's plans to put together his own band in Witch World makes Sabrina's job much more difficult.
Time freezes in the human world when Sabrina accidentally loses the magic hourglass that regulates time between both the human and witch worlds.
Sabrina is forced to cancel her plans with Jim when Enchantra insists that she and Shinji have a romantic dinner together in Witch World. Note: The title is a parody of the song Breaking Up Is Hard to Do.
When Shinji kidnaps a baby dragon during a class assignment, it gets loose in the human world with a bad case of fiery hiccups in the form of fireballs. Sabrina must find and return it to its mother, who is angrily attacking Enchantra and the other wizards and witches until her baby is safety returned.
Enchantra turns Sabrina and Jessie from best friends to sworn enemies by hiding fighting sprites in their true friendship bracelets. Sabrina, being half-witch, manages to break free and now she must save Jessie before she hurts herself and their intense friendship.
During a full moon, Harvey turns into a werewolf and runs amok. So Sabrina and Veralupa try to get him back home safely.
In order to recharge and further strengthen their magic wands, Sabrina and her friends are at the healing stone. However, an extremely powerful energy vortex created from increasingly believed human superstitions threatens to destroy all of Witch World.
The kids engage in a role-playing game in the woods. But the game soon becomes a reality after they unknowingly enter the magical world via a secret mystical portal hidden in a tree.
Sabrina gets amnesia and is abducted by trolls, who is tricked into thinking she's a princess of trolls. Before long, the trolls use her powers to ambush witch school.
Sabrina is roped into baby sitting but it doesn't take long for magic to make things worse.
A nightmare is shared by Sabina and her pals, and it originates from a Witch World creature, so Sabrina enters Jesse's dream to wage war on the monster
Sabrina must be the responsible one when her aunts become teenagers all over again.
Harvey believes Sabrina is a superhero when he sees her use her powers.
Sabrina calls on a member of the Witch World to help when Spellman's Brew faces being torn down.
Harvey finds Sabrina's wand and uses it in his magic act in the school talent show.
Sabrina and Shinji search Greendale High to find the cause of an illness that is causing the witches to lose their magic. The bickering pair must hurry as the trolls plan an attack on the weakened witches.
To earn money to buy a birthday cake for Jim, Sabrina gets a job making deliveries for her aunts. But her job becomes all the more difficult when Veralupa accidentally traps Shinji inside of her scooter.
Tired of doing Enchantra's bidding, Salem runs away and takes on the form of a human. But when Enchantra sends a dangerous shadow spirit to do her bidding, Salem must choose between a free or feline life.
Enchantra sends Sabrina and Shinji on the Journey of Ten-Thousand Steps; a trek through treacherous realms of Witch World. While they learn to work together, Hilda transforms into Sabrina to cover for her at Greendale High.
Sabrina frees an overeager genie, who insists on granting every one of her wishes - and the wishes of everyone in Greendale.
Enchantra's sister banishes Sabrina and Enchantra to Human World, where the unlikely pair must work together to get back through the portal and regain control of Witch World.
