Reed siblings Alex, Georgie, Teddy and Frankie are brought together by the sale of their family home, an event that disturbs their recently widowed mom.
On the eve of her 15th anniversary, Alex learns her marriage may not be as healthy as she thought.
Georgie pressures Frankie to hire Teddy; Alex and Wade attend counseling; Teddy resents the gifts Frankie is buying for Cat.
Georgie considers romance with an old flame; Frankie learns of a woman in their father's past.
After a fight with Frankie, Mitch calls a party line and unknowingly gets Teddy. Georgie asks for a promotion and invites her boss to dinner. Unfortunately, as she carves the goose, she finds Evan's pet cooked inside. She gets the promotion.
Frankie and Mitch's impending nuptials stress Teddy.
Mitch gets Cat while Teddy wanders; Georgie remains stoic during her son Evan's hospital stay.
Alex plans a birthday bash for Evan; Georgie fears tippling Teddy will cause trouble; Frankie is torn between business and pleasure.
Wade and Alex pose for a portrait, but his secret mars the session; Hank and model Teddy work well together; Mitch asks Frankie for monetary help.
Alex plots divorce; Wade's girlfriend schemes; Frankie and Mitch agonize over breaking the news; Teddy makes a self-discovery. Georgie competes in a bowling tournament with friends from work and they win.
Teddy and Mitch search for runaway Cat; Alex vows to get wild.
Alex encounters an old flame at her high school reunion; Georgie and John try to restore passion.
An exhibit of nude photos of Teddy shocks the family and incites a councilman to close the exhibit and put Teddy in jail.
Teddy reveals her pregnancy; the sisters witness their mother's romance with a judge.
Alex joins a dating service, then has an affair with her plumber; Frankie's meddlesome mother-in-law visits; Georgie wars with a neighbor.
Georgie revisits the old Reed home and relives past Thanksgivings; collegiate Reed returns from France.
Turning in a harassing office Romeo could ruin Frankie's business deal; Teddy has another emotional setback.
Spoiled eggnog ruins Christmas Eve; Frankie sees Mitch comfort Teddy; the ghost of Christmas past visits Teddy.
Georgie confronts the school board over ousting an HIV-positive teacher; Alex fights her maid's deportation.
Alex can't decide whether to go to awards ceremonies for Wade or for Victor; Frankie chooses Mitch's fishing trip over business.
A secretary complains of sexual harassment by the executive who promoted Frankie; Teddy sells cosmetics door-to-door.
Georgie runs for the school board; Alex fibs to get Reed into private school; Frankie and Mitch try to unload a defective stove.
The sisters help out when a fire destroys Teddy's designs on the eve of a showcase; Frankie and Mitch calculate when to conceive.
The siblings' various duties distract them from their mother's life-threatening condition.
Mugging victim Alex springs for a high-tech security system; Teddy learns of Cat's romantic plans; John gets stage fright at a nightclub.
Alex considers selling her home to pay a deadbeat client's debts; the sisters try to cheer their despondent mother.
Teddy tries romance with a recovering alcoholic; Wade shells out to get Alex back; Georgie is jealous of John's singing partner, Fern.
A single mother offers her newborn to Frankie and Mitch for adoption; Alex puzzles over how to tell Victor she's returning to Wade.
Siblings volunteer to carry Frankie and Mitch's embryo; Teddy may have to hire an ex-convict; Alex gets hooked on a soap opera.
Alex sweats out her mother's wedding day; pregnant Georgie resents Frankie's pampering; collegian Cat's departure saddens Mitch and Teddy.
A corporate magnate offers Teddy a lucrative deal for her apparel business; Georgie's binging in her last weeks of pregnancy alarms all.
Frankie dreads telling the family she's going to convert and raise the children in the Jewish faith; Alex hovers around her newlywed daughter.
Georgie flashes back after learning John's plane crashed; Bolt coaches Teddy for a news conference spotlighting her line.
A visit to Cat's college makes Teddy fear her daughter will become an alcoholic; Alex clashes with animal-rights activists.
Teddy unearths her boss's tragic childhood secret; Alex thinks she killed a homeless man; Frankie and Mitch spend the night in a haunted house.
The women search for a $60 million lottery ticket Bea lost; Teddy answers to Bolt for firing his employee.
In a car accident, Georgie goes into labor while pinned in the vehicle.
Nervous Teddy prepares for her fashion show; a prominent women's club asks Alex to join because of Teddy's celebrity; new mother Frankie depends on Georgie too much.
Jealous of Teddy, Alex launches her own jewelry line; Frankie feels threatened by her mother's ease with the baby; Reed must choose between her husband and her father; Mitch and Bolt face off to see who's the ""best"" man.
Teddy learns her high-school beau has AIDS; Frankie over-mothers Trevor and Evan while Georgie vacations; Alex's idol pans her writing.
Frankie anticipates her first Hanukkah, while Mitch's shop is defaced with Swastikas; Reed and Cat try to reconcile their mothers.
Restless Frankie wants to curtail her maternity leave, putting her at odds with Mitch; Teddy cautiously agrees to live with Simon.
Teddy declares war on a fashion critic; Georgie back over a neighbor's chihuahua.
A screenwriter profiles Georgie's surrogacy and starts family fights; Alex tries to get Reed and Kirby to leave.
A fired employee takes Teddy hostage, but Bolt offers himself in exchange; Wade tells Alex he is remarrying.
A TV movie on the sisters unites Alex with her romantic idol.
Alex faces some difficult decisions when her doctor finds a lump in her breast; Frankie tries to resurrect her love life with Mitch; Georgie has a crisis of faith.
Worry over chemotherapy makes Alex more sarcastic; Teddy offers to sell her shares to help Simon ward off a takeover; school officials notify Georgie and John that Evan is a genius.
Georgie is hired to write an advice column for the local newspaper; John thinks Teddy has fallen in love with him; Alex and Frankie accuse Truman of cheating on their mother.
A podiatrist romances Alex; Frankie spends time with an executive; Georgie and John try to rekindle romance.
Simon proposes to Teddy; Alex buys a wig from a mystic who claims it has powers; Frankie and Mitch consult a marriage counselor.
Moving into a new house makes Mitch confront Frankie; a diminutive Texas billionaire buys out Teddy's firm and they lock horns over a discount clothing line; Kirby is accepted into a film school in Los Angeles.
Frankie accepts a job in New York; a comedian teaches Alex how to perform stand-up as a way of coping with her disease.
Georgie gets caught in the middle as Frankie and Mitch battle in court over Thomas George; Cat trains Alex for a marathon; the first lady seeks Teddy's services and inspires her to return to fashion design.
Teddy decides to take the law into her own hands and avenge Cat's attack while Cat lies on the brink of death; Reed joins a religious cult.
Teddy and Mitch assist Cat's recovery and spend a night together; Falconer encourages Cat to remember so she can identify her attacker; Alex goes to California to visit Reed and Kirby.
Alex takes her story of survival on a talk show; Teddy and Mitch mull reconciliation; Frankie and Georgie try to convince the owners of the ""Sweet Sixteen"" ice cream shop to rebuild.
Teddy overreacts when Kyle makes bail; Frankie prepares for a date with a man she met over her computer; John wants to perform on Alex's show.
The family supports Cat through the rape trial; the ordeal prompts Georgie to reveal a secret from her past.
Georgie and John find Trevor in a compromising position; Teddy and Falconer become closer; Alex learns an interesting fact about Norma.
Simon Bolt returns from the dead; Alex and Truman plan a surprise party for Bea; ""Sweet Sixteen"" reopens and Frankie has second thoughts about hiring Trevor.
Frankie helps her father's one-time mistress, now a homeless woman; Teddy hires Bolt as her assistant; Mitch and John take Evan and Trevor on a camping trip.
Falconer learns Bolt is wanted in London for embezzlement; the family tries an ""intervention"" with Trevor.
The sisters prepare for Christmas; Trevor is sent to rehab; Alex's show is cancelled; Teddy tries to help Falconer through memories of his son's death.
A disastrous introduction to Alex's family prompts seconds thoughts about Big Al; Falconer's work-related injury alerts Teddy to the risks of dating a cop; Frankie begins to wonder if she can handle running the ""Sweet Sixteen"".
Depressed and confused, Georgie contemplates suicide while Trevor is at the rehabilitation center and John and Evan are away, but her efforts are thwarted when the 'sisters' get snowbound at her house.
Alex dates a doctor who makes her miss Al; Teddy believes an art-gallery owner's accidental death was murder and is determined to solve the crime; Georgie fears she will become addicted to the anti-depressants her doctor prescribed.
Trevor runs away from the rehabilitation center; Teddy doubts Falconer's innocence in an excessive force case; a new assistant aims for Alex's job as host.
Falconer goes off the wagon after his suspension; Alex confronts her ambitious assistant; Thomas George is wanted for a commercial.
Teddy summons the courage to propose to Falconer; Alex and Al marry after he proposes on the air; Evan plots to reunite Georgie and John; Truman asks Bea for a divorce.
The sisters learn they might have a half-sister; Mitch encourages Frankie to date; Teddy fears she has lost Falconer to his ex-wife.
The sisters await results of their blood tests and Frankie resents Charley's refusal to be involved with the family; Alex and Al await the verdict in his tax-fraud case; Cat has her first date since the attack.
Teddy spots Trevor living on the streets of Chicago and tries to convince him to return home; Alex invites Norma's parents to Winnetka when Norma wins an award.
Pregnant Reed returns to learn Alex may have cancer again; Falconer is assigned to protect Teddy from a stalker.
Naomi Judd appears on Alex's show, then must deliver Reed's baby; eloping Teddy and Falconer fly into a storm.
No one believes Georgie when she has memories of being sexually abused by her father; Teddy and Falconer begin their lives as newlyweds.
Teddy suffers from blindness after witnessing Falconer's murder; the rift between Bea and Georgie grows as a result of Georgie's claims that she was molested.
Frankie learns that a former client has died and left her a boxer in his will; a dying fan wants Alex to raise her child; Teddy receives a surprise visitor.
Teddy resorts to alcohol while struggling with Falconer's death; Georgie feels betrayed by John when he visits Dr. Caspian; Grace takes a turn for the worse.
Big Al's life changes when he rescues the governor's wife from drowning in the prison pool; Lucky disappears just as Frankie gets him the match of his career; Teddy meets an unsavory character at a bar.
After Dr. Caspian encourages Georgie to fantasize, she's surprised that he's the object of her thoughts; Big Al hits the campaign trail, but scandals threaten to derail his bid; Teddy gets an intern---who may be her ticket to impressing a prospective client.
Teddy has a near fatal accident and sets out for a rehab program; Alex---as the mayor's wife---constructs a ""kitchen cabinet"" and appoints a reluctant Georgie to fill a ""devoted wife and working mother"" position; Georgie confesses to Alex about her affair with Dr. Caspian; Frankie wants Lucky to withdraw from a fight with Cyclone.
Although Georgie cancels the annual Thanksgiving dinner at her home, family members--including half-sister Charley--gather there anyway to support Bea, who's coping with an ailing Truman; Alex views a videotaped message from Truman in which he makes a surprising request of her; and Teddy shows up with her roommate from rehab---a popular rock singer.
Alex and Big Al cancel their belated honeymoon when Roxie's mother dies; Georgie attends a psychiatric conference where Dr. Caspian is a speaker; Teddy recruits Lucky for a fashion show, but their pairing makes Frankie thinks her relationship with the boxer is on the ropes.
Friends at a college homecoming try to convince Georgie and John to stay together; Truman is admitted to a nursing home; Alex attempts to nurse an ill Teddy back to health so they can attend a concert.
Frankie hopes for a miracle when Thomas George disappears from a Christmas tree lot; Norma asks Big Al to donate sperm so she can have a child with her partner.
Georgie is left in the cold after leaving John for Dr. Caspian ; Alex speaks out on a controversial issue, and Norma is forced to fire her; Teddy and Cat go to a health spa.
Georgie decides to bring Dr. Caspian up on ethics charges before the medical licensing board; Alex receives surprising news about Roxie.
Charley tries to expose Dr. Caspian as the unethical therapist he is; Alex shares Truman's living will with Bea ; Frankie is a big hit as a bovine.
Roxie's father decides to move to St. Louis and take Roxie; John concludes that his marriage can't be saved and serves Georgie divorce papers; Teddy learns Cat's new boyfriend is a 40-year-old married professor, that she used to date.
Teddy takes matters into her own hands when Falconer's killer is freed for agreeing to testify against drug lord Daniel Albright; Alex helps Truman end his suffering; Frankie moves to Japan to market ""Cowlotta"".
Alex decides to face a murder trial in the death of Truman; Teddy pretends to be interested in Albright; Charley discovers her new boyfriend is schizophrenic.
Teddy and Lucky fear Albright is onto their charade, so they fake Lucky's death. Charley and Georgie get the evidence they need against Dr. Caspian. Alex fights media attacks.
An unsympathetic judge presides over Alex's trial. Albright's wife confronts Teddy. Cat's married boyfriend makes plans to leave his wife, but Cat leaves him.
Teddy obtains the evidence she needs against Albright, but plans are endangered when his associate becomes suspicious of her actions. Alex helps Norma with a PBS telethon. Charley quits her job at Lakeview Medical Association and returns to the free clinic.
The sisters reach turning points in their lives and Aunt Gigi's stories about her own sisters helps to point them in the right direction.
Jack Chambers, the recipient of Falconer's heart, contacts Teddy. Evan gets boxing lessons from Lucky after an incident with a bully. Charley offers Bea a job at the clinic.
Teddy starts a romance with Jack. Alex becomes mayor for a day when Big Al has a heart attack. John and Georgie learn that Trevor has enlisted in the Army.
Love is in the air when the sisters decide to take a break and head to a south-of-the-border resort for some rest and relaxation.
Georgie tries to put her life back together; Reed returns to Winnetka without Halsey and Kirby; Teddy and Cat are car-jacked when they take a spin in Cat's graduation present, so Teddy decides to buy mother-daughter pistols.
Wounded Teddy falls into a coma; Georgie seeks solace from Brian; after spending time with Billy, Cat decides to be a cop.
Roommate Reed saves Cat's life from a gas leak; Trevor visits Georgie and meets Brian; a former college beau, now a fugitive, seeks Alex's aid.
After her release from the hospital, the family tries to trigger amnesiac Teddy's memory by relating stories of her past. Deciding she has caused her sisters enough pain, she hits the road.
After Norma gives birth, her mother files a custody suit for Allie; Georgie and Brian spend a weekend together; romance sparks between Teddy and her life-saving doctor.
Alex makes a sad discovery; Teddy learns her company's board may replace her; Charley mulls becoming a foster parent to Jesse .
Alex's denial of menopause leads to strange behavior; Evan's decision to live with his father devastates Georgie.
Almost everyone approves of Georgie's new beau; Teddy and Kiri clash over a fashion fair; Charley learns the ropes of parenting.
Billy's ex-convict father saves Alex's Thanksgiving dinner, but then her diamond ring disappears; Gabe's troubled daughter drops in.
Teddy confronts Gabe about another woman; Alex inspires a rich man's contribution to the ballet; Wes worries about Jesse.
Alex begs Reed to close the escort service; Cat is asked to gather evidence about Reed's business; Georgie becomes obsessed with John's hit song.
Reed is sentenced to community service in an AIDS hospice; Big Al learns he needs a heart transplant; Gabe fades in the shadow of Teddy's spotlight.
Cat investigates Teddy's carjacking, hoping to find the man who almost killed her mother; Big Al plans for his own demise.
Teddy considers becoming the fourth Mrs. Sorenson; Alex challenges a critical journalist to a debate; Wes announces plans to move to Detroit.
Alex vies with her new co-host Pug Finnigan, to win an interview with a local hero; Reed is able to help fulfill the wishes of a dying AIDS patient.
The family fears that Teddy will suffer the 'wedding curse'; Alex tries to ensure a speedy heart donor for Big Al.
Immediately after the wedding, the family members gather at the hospital to await the arrival of the heart for Big Al's transplant.
Mom and the sisters reminisce when a sudden snowstorm strands all five women in a limousine on a deserted road.
Alex and Norma try to gain admittance to Pug's 'men only' cigar club; Trevor comes home from the Army on a weekend pass.
Trevor is reported missing in action while serving in Korea; Bea and Billy's father consider buying the 'Sweet Sixteen' from Georgie.
Alex persuades Reed to fight for joint custody of her daughter; Gabe mourns the death of a patient who was also one of his students.
Alex is delighted to learn that her show might be broadcast nationally, but is hesitant about the sacrifices involved.
Big Al is inspired to delve into his own ethnic heritage after meeting a prospective business partner who is an overt bigot; Wes' parents visit. Georgie thinks that she might be pregnant.
When Alex's show is canceled and Norma is offered a new job as a producer immediately, jealousy threatens their relationship.
Alex finds that she has an abundance of free time after her show is canceled; Georgie and Brian are at odds over advice they give to a troubled married couple.
Teddy and Gabe resort to drastic measures to produce a baby; Charley and Wes realize that being married will make it easier for them to adopt Jesse.
Georgie presents each of her sisters with a copy of her graduate thesis - which is about them; Frankie returns from Japan when Bea suffers a massive stroke.
The sisters decide to go there separate ways after Bea's death, believing it was her that held the family together - until she visits each of them.
Part One: In Conversation with series creators Ron Cowen and Daniel Lipman.
Part Two: In Conversation with series creators Ron Cowen and Daniel Lipman.
Part Three: In Conversation with series creators Ron Cowen and Daniel Lipman.