On his first night at work at the Daily Bugle, Peter overhears talk of a fake medicine racket engineered by a rotund mobster called the Kingpin, whose thugs have a laboratory somewhere where they produce cheap, imitation pharmaceuticals, which are then peddled at gunpoint to druggists, who are subsequently frightened into selling the fake medicine and not signing a complaint for the police.
A twisted radiation specialist gains illicit dominion over Manhattan's new and only nuclear power plant and uses a special ray to lift Manhattan into the clouds, and unless he is amply paid, granted amnesty from arrest, and permitted to build his own nuclear reactor, he will deactivate the ray and plunge the island by force of gravity back down to Earth.
Investigating the disappearance of banks (which have been mechanically submerged to deep inside the Earth), Spidey finds a hole that leads to a maze of underground tunnels, through which Spidey undertakes a perilous journey in search of the lost occupants of the submerged banks, and he comes upon a bizarre city populated by group of Molemen led by a maniac intent on conquest of the "surface people", some of whom- the occupants of the banks-the Molemen are holding prisoner.
A baseball diamond and the spherical, baseball-sized Optimo Diamond at the Cosmopolitan Museum are connected in this episode as Peter, about to be the star pitcher in a collegiate baseball game, is obliged to don his Spidey-suit once to stop a rampaging ape at the New York City Zoo and again to thwart men in ape disguise at the museum from stealing the Optimo.
Mugs Riley, evidently escaped from prison, has duped the Molemen into following him again, even though they angrily deposed him in "Menace From the Bottom of the World", and arranges for Spiderman to be attached to a building so that the web-swinger will be brought underground along with the building, to face the revenge of Mugs Riley.
In ancient Egypt, one of the most aggressive of evil magicians, Kotep, the Scarlet Sorcerer, is defeated in battle with an opponent, and his own demons strike him with a cursing ball of fire that puts him in suspended animation, his mummified remains lasting through the passing centuries and becoming an exhibit at a New York university and the object of a professor's obsession.
A giant plant escapes from storage in a house belonging to Prof. Smithers, a missing scientist. Spidey goes through a portal (located in the scientist's home) to prehistoric times to find some defense against the plant and meets Smithers, who tells to him that two radium gems in an idol in a nearby city, if ingested by the plant in New York, will disintegrate it.
Pardo is a sorcerer with the ability to transform himself into a giant cat with hypnotic eyes. He lures top New York City citizens and officials to a theatre with the promise of a spectacular show, then releases his feline alter-ego's power upon the hapless audience, intending to divest them of their wealth and sap the souls out of their bodies.
Peter is an exchange student in South America, flying in a charter airplane with a Latin American professor in the Andes mountains. The airplane encounters a violent storm and crashes in a jungle, and Peter changes to Spiderman to assist the professor and the airplane's two pilots in leaving the jungle and returning to civilization.
The weird Dr. Atlantian rises out of the ocean near New York City in his hive-like machine, which derives its power from Lunar motion. Atlantian represents the lost continent of Atlantis, which has developed an advanced technology in its centuries of undersea existence and now intends to conquer the surface world.
A remake of Season 2's "Vine", virtually identical in plot; the only difference is that instead of a giant plant threatening New York, the menace is a series of enormous, rolling pods that grow from boxes in a missing scientist's house. The scientist has used a time portal located in his house to journey into another dimension, and the rolling pods have come from that dimension, the Land of Crystal Creation.
A dying scientist from the destroyed planet Goth in the deceased galaxy of Kamosah must land his crippled spaceship on Earth and, before expiring, entrusts Spiderman with a tiny but encyclopedic library of information, including the secrets of a dimension of living thought, whose one-eyed, skeletal ruler, Infinata, wants this information destroyed.
Jameson orders Peter to fly in an airplane with Daily Bugle pilot Osa Olsen to the North Pole to locate a fallen meteor with bizarre antennae, but a thunder-snowstorm cripples Parker and Olsen's airplane, and it crashes in a wasteland populated by a tribe of savages, who have appropriated the meteor and are planning to drop it into a volcano as an offering to their fire god in return for warmth.