Adrienne and her cat Langston are planing a quiet weekend in a psychiatric clinic to recover from their arachnophobia (fear of spiders). Itsy is secretly traveling with them in their luggage.
Adrienne is invited to a cooking show on television. Itsy is curious and comes along.
Itsy's little friend Leslie wants to study karate. She registers to take lessons at Adrienne's studio. Itsy decides to join her.
Leslie goes camping in the mountains with her Girl scout troop. Itsy travels in her luggage.
Adrienne has hired a gardener, to beautify her garden for an important meeting with the "Committee against dirty things". But the gardener is old and short sighted, he love flowers, so he won't cut them.
The cat, Langston has caught Itsy and Adrienne wants to sell him in her pet shop. Itsy is put in a glass bowl in Adrienne's shop in a huge shopping mall.
Adrienne takes Langston and Leslie on a cruise. Leslie would never go on such a long trip without Itsy.
Itsy and Leslie are watching TV. They are bored. Suddenly they hear that a circus is marching through town.
Leslie, George and Itsy go skiing. Because George does not know how to ski, he has to take ski lessons.
Itsy and Leslie visit the Paranoid Studios in Hollywood, where Leslie takes part in a talent competition.
Itsy and Leslie go shopping in the supermarket. Itsy is especially fascinated by the huge freezer filled with innumerable types of ice cream. Too bad, Adrienne also wants to buy some ice cream.
Leslie and George are taking ballet lessons. The director Adrienne is convinced that both have no talent at all. It's no wonder, Itry tries to help them.
Itsy and Leslie are reading a book about spiders. The most fascinating story is about the "Black Widow". They are shocked by the fact that this spider kills and eats her husband.
Itsy and Leslie go to a dude ranch run by Adrienne for well-behaved young adults. While they are there, cattle rustlers take over the ranch.
Adrienne discovers her cat, Langston, will inherit million, if only they can spend the night in her crazy old Aunt's castle.
George is in the hospital recuperating from his tonsillectomy when Leslie and Itsy come to visit.
When Adrienne eats Leslie and George's picnic lunch, the children must find a way to get some food on their own, so they enter the sand castle building contest in hopes of winning all the food they can eat.
George needs the autograph of one more wrestler to complete his collection; and he's determined to get it at the Rock-o-Rama Wrestling tournament.
Itsy becomes an accidental stow-away on a spaceship headed for the planet Poog.
Leslie, George and Itsy are off to the local fast-food burger joint to find out how a real business works.
Itsy decides to tag along with Leslie as she's off to school for the day.
At the city zoo, Itsy and Leslie discover Elliott, a rare white elephant who wants desperately to return to his original wild-animal preserve home.
A day at the local state fair becomes an even bigger adventure when Itsy and Leslie have to outwit Adrienne and the Exterminator.
Leslie is visiting her grandparents for the day. It's Itsy-to-the-rescue when a greedy land developer and her construction foreman try to evict the tenants from the Happy Meadows Old Folks Home.
Leslie is spending her summer as a caddie at a snooty country club, where she is teamed with golf-pro Adrienne and her young nephew Wallace.
Itsy, Leslie and George take a tour of Aunt Addie's Chocolate Factory for some free samples.
A young country spider Itsy befriends Leslie McGroarty, a perky young city girl who takes piano lessons from the music teacher (incidentally, she learns to play the real rhyme) and her cat, Langston. When Itsy frightens the teacher, she calls the Exterminator, who tries to kill Itsy with the toxic machine blower, but it causes pain and destruction to the instructor's house, and the Exterminator turns out to be a heavily armed android. The Exterminator's method uses more extreme weapons, escalating from poison and vacuums to guns and explosives, and it destroys the instructor's house. Itsy finally reunites with Leslie (who senses to leave the house when the Exterminator uses the weapons) and head home to the big city with the bicycle.