It's 2418 and the Planetary Union promotes Ed Mercer to Captain of the exploratory vessel The U.S.S. Orville. Ed's enthusiasm for his new position is dampened when his ex-wife, Kelly Grayson, is assigned to be his First Officer. While on their first routine mission, the Orville crew is ambushed by the Krill, a vicious alien race, who are bent on stealing a device that can cause time to accelerate.
Ed and Kelly seriously reconsider getting back together. However, while Kelly is on a mission with Isaac and Gordon to investigate the origins of an uncharted star, they suddenly crash-land on a planet from another universe. Kelly then makes a decision with unforeseen long-term consequences for the planet, putting Ed in a difficult position.