Mr. Magoo is asked by his neighbor Mrs. Roberts to babysit her children. But Magoo and McBarker mistakenly go to a spaceship occupied by two friendly green aliens wanting to experiment with them, leading into out-of-this-world gags!
Magoo and McBarker go hunting for a Lion and get mixed up with all kinds of animals.
Mr. Magoo plans to spend the night at a nice motel, but mistakenly enters a haunted mansion. Luckily, he leaves the mansion before the vampire who lived there and his assistant could get him. However, when Mr. Magoo arrives at the motel, he mistakes it for a haunted mansion.
Magoo inadvertently saves the day when the train he is on is boarded by an Old West train robber.
Magoo and McBarker get mixed up with a spy and his secret plans for the XB4265-C, a nuclear powered blimp.