A supernatural Witchblade becomes part of cop Sara "Pez" Pezzini's arsenal - if she can master it.
Learning to adapt to the Witchblade, and her new partner Jake McCarty, Sara Pezzini's role in the Rialto Theater incident is questioned during a hostile meeting with the police review board. Captain Joe Siri makes a big announcement. Sara and Jake tangle with Ian Nottingham over a deranged ex-special forces soldier a "Black Dragon". Captain Bruno Dante is introduced.
When Sara and Jake investigate the murder of a prominent Soho art dealer, they quickly narrow their search to an artist who turns out to be one of an unknown number of identical brothers connected to the myth of the Witchblade. Sara seeks answers about the Witchblade from the incarcerated Madame Dominique and internet artifacts dealer, Gabriel Bowman.
A priest is brutally killed, and a young member of his congregation is the prime suspect. Despite the boy's affirmations of guilt, Sara suspects something else is at work. Investigating, she comes to believe that the boy was possessed by demons, and yet she still believes he was not the one responsible. She also fences with Father Del Toro, who has been assigned by the Vatican to investigate. Del Toro seems to know a great deal about the Witchblade as well, from its time when it was kept at the Vatican. Eventually Del Toro is revealed as the true murderer.
Sara's unlikely protector surfaces with a life-threatening passion to watch over her that leads to irrevocable consequences. Sara has no choice but to accept the destiny that comes with wielding the gauntlet and use it to regain what she has lost. But every gain has its price. True to the words of the Witchblade's past wielders, "Nothing is as it seems". A startling discovery about Dante and his team of corrupt cops lead to a suspenseful showdown between the rising warrior and a band of enemies that she must conquer before her father's killer is revealed.
Sara Pezzini and her partner Danny Woo are once again in pursuit of the allusive mobster Tommy Gallo. As before, Tommy's henchman lures Sara into the museum where she encounters the Witchblade and it claims her as its chosen wielder. This time, however, things are different. Though it's a case of deja vu as she retraces her steps to the Rialto Theater, an older and wiser Sara declines the opportunity to confront Gallo inside. Although the past may be altered, Kenneth Irons has plans for the future and he determines to take the Witchblade from Sara even if it means having her killed. A much conflicted Ian Nottingham finds his loyalties split between guarding the chosen Witchblade wielder and carrying out the wishes of his master/father, Irons. Using an online murder/hit as bait, Irons lures Sara into his clutches while promising an ambitious and cold-blooded woman named Cristina that she will wear the Witchblade if she takes out Sara. To do so, Cristina must first get rid of Danny so she buries him alive, leaving him to die a horrible, slow death. In a Witchblade frenzy, Sara kills Cristina before she can make her tell what she did with Danny. As her partner runs out of air in an unmarked grave, Sara desperately searches for him before it's too late.
A killer known only as V tries to take over New York's organized crime syndicates, causing mayhem. But when the evidence gathered at the crime scenes includes the fingerprints of Sara's long-dead father, Sara must trust the Witchblade's powers to overcome her emotions and wage war with the greatest evil she has ever faced.
A man named Bittner is on the run from two mysterious men who kill him after he sends a message to Gabriel. It turns out Bittner had a tape with evidence convicting the mysterious men and their organization of some major murder. Gabriel and Sara recover the tape, are forced to shoot two of the men who are government types, and go on the run while Sara has visions of a mysterious Boston-accented talking to her about politics and evil. Sara ends up captured by the conspiracy, who are a mysterious cabal who plan on taking over the U.S. She escapes but the conspiracy lets her live in return for a favor, and returns the captive Gabriel to her. At the end her mysterious ghost/man reveals himself as John F. Kennedy before disappearing.
A link to unusual circumstances and the mysterious tatoos on the murder victims lead Sara and Jake to investigate other hate crimes that have been interrupted but are occurring across the city. It becomes apparent that a vigilante is trying to thwart the efforts of the hate crime perps. Sara goes undercover to find out more about the tatoos that are traced to the Lupo organization and its mysterious leader, but when her disguise is blown, she must use the Witchblade to escape
Jake and Danny go undercover posing as hot-headed fighters to investigate the murder of a young man who was in an underground fight club. But the deadly game becomes complicated when Sara's long-lost love, Conchobar (Kim De Lury), steps into the ring. In a bizarre twist of fate, Sara finds herself risking everything - including the Witchblade - to save her lover and bring the killer to justice.
Sara awakens from a nightmare to discover the Witchblade gone and New York City in chaos after a bizarre homicidal spree. When she finds that the killers recently accessed Cyberfaust.net, a Web site run by someone who knows about the Witchblade, Sara suspects Irons. Risking her sanity, she peruses the site and becomes helpless due to Cyberfaust's spell. She is forced to battle against the Witchblade and its diabolical new wielder.