British Museum curator Lady Alex Lindo-Parker jets off to the Amazon in search of Victorian explorer Percy Fawcett's lost camp, but after encountering one or two minor mishaps, she is thrown together with maverick American adventurer Hooten. The pair stumble upon El Dorado - the fabled city of gold - but there are rival explorers lurking behind every tree to make sure that getting their hands on any treasure won't be an easy task.
In Rome, Lady Alex helps Hooten search for the Sibylline Books but quickly ends up scaling the Sistine Chapel, battling an alligator and clashing with the mafia.
Lady Alex heads to Egypt, where she teams up with Hooten to find the long-lost tomb of Alexander the Great. But some unscrupulous locals are hot on their heels.
Lady Alex and Hooten head to the remote Himalayan kingdom of Bhutan in search of an ancient scroll rumoured to have been written by the Buddha himself.
When Ella is kidnapped in Ethiopia, Lady Alex and Hooten head to Africa where they they must overcome crazed bandits and surly camels in order to save the day.
Lady Alex jets off to Moscow to help Hooten in his search for a lost Faberge egg and confronts her arch enemy from university, who now works for a shadowy black market collector, but they soon become entangled in a sinister criminal underworld.
Lady Alex and Hooten attempt to track down the priceless Cintamani jewel in Cambodia, but they quickly attract the attention of a ruthless drug gang.
Alex puts her wedding in jeopardy as she follows Hooten to an idyllic Caribbean island, searching for Captain Henry Morgan's buried pirate treasure. With half a map each and other hunters on their tail, this larger-than-life expedition threatens to derail the biggest day in Lady Alex's life.
