Three best friends from Los Angeles (hopeless romantic Melanie, cynical businesswoman Joy, aging actress Victoria) are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that the social norms from SoCal no longer apply, and thrilled by their liberating possibilities in Ohio, they decide to celebrate a city that values 'real women' and stay where they're considered 'hot'.
Joy tries to take advantage of her newfound appeal in Cleveland by dating a much younger man, but her new relationship ends up exposing an old secret. Meanwhile, Melanie encourages Elka to date again by helping her decide between a bevy of men. Victoria gets hooked on Big N Easy, where she goes for the savings and stays for so much more.
Melanie throws a party to meet their neighbors and she comes off as insulting to one of her next door neighbors (Wayne Knight), a columnist for The Plain Dealer, leading Melanie to fear that he'll write something negative about her. Meanwhile, Victoria gets a offer to do a commercial for underpants in Japan and Elka sports a dyed hairdo that draws criticism from Joy.
A pair of 'magic SPANX' come into the ladies' lives and leads them to unexpected adventures. Joy seeks love, but ends up with a much, much younger man. Melanie wants to catch the eye of a doctor and ends up with all eyes on her. Victoria dons the SPANX for a big audition, but ends up in a major catfight with Melanie Griffith. Elka just wants her team, the Cleveland Indians, to win.
A behind-the-scenes look at the season-premiere episode, in which Elka and Mamie's illegal business activities are revealed.